prikaz prve stranice dokumenta Key Factors in the Complex and Coordinated Network of Skin Keratinization: Their Significance and Involvement in Common Skin Conditions
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Scientific paper - Review paper
Key Factors in the Complex and Coordinated Network of Skin Keratinization: Their Significance and Involvement in Common Skin Conditions
International Journal of Molecular Sciences, 25 (2023), 1; 236. https://doi.org/10.3390/ijms25010236
Pondeljak, Nives; Lugović-Mihić, Liborija; Tomić, Lucija; Parać, Ena; Pedić, Lovre; Lazić-Mosler, Elvira

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Pondeljak, N., Lugović Mihić, L., Tomić, L., Parać, E., Pedić, L. & Lazić Mosler, E. (2023). Key Factors in the Complex and Coordinated Network of Skin Keratinization: Their Significance and Involvement in Common Skin Conditions. International Journal of Molecular Sciences, 25. (1). doi: 10.3390/ijms25010236

Pondeljak, Nives, et al. "Key Factors in the Complex and Coordinated Network of Skin Keratinization: Their Significance and Involvement in Common Skin Conditions." International Journal of Molecular Sciences, vol. 25, no. 1, 2023. https://doi.org/10.3390/ijms25010236

Pondeljak, Nives, Liborija Lugović Mihić, Lucija Tomić, Ena Parać, Lovre Pedić and Elvira Lazić Mosler. "Key Factors in the Complex and Coordinated Network of Skin Keratinization: Their Significance and Involvement in Common Skin Conditions." International Journal of Molecular Sciences 25, no. 1 (2023). https://doi.org/10.3390/ijms25010236

Pondeljak, N., et al. (2023) 'Key Factors in the Complex and Coordinated Network of Skin Keratinization: Their Significance and Involvement in Common Skin Conditions', International Journal of Molecular Sciences, 25(1). doi: 10.3390/ijms25010236

Pondeljak N, Lugović Mihić L, Tomić L, Parać E, Pedić L, Lazić Mosler E. Key Factors in the Complex and Coordinated Network of Skin Keratinization: Their Significance and Involvement in Common Skin Conditions. International Journal of Molecular Sciences [Internet]. 2023 December 23 [cited 2024 May 09];25(1). doi: 10.3390/ijms25010236

N. Pondeljak, L. Lugović Mihić, L. Tomić, E. Parać, L. Pedić and E. Lazić Mosler, "Key Factors in the Complex and Coordinated Network of Skin Keratinization: Their Significance and Involvement in Common Skin Conditions", International Journal of Molecular Sciences, vol. 25, no. 1, December 2023. [Online]. Available at: https://urn.nsk.hr/urn:nbn:hr:127:500792. [Accessed: 09 May 2024]

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Metadata
Title (english)Key Factors in the Complex and Coordinated Network of Skin Keratinization: Their Significance and Involvement in Common Skin Conditions
AuthorNives Pondeljak
AuthorLiborija Lugović-Mihić
MBZ: 215056
AuthorLucija Tomić
AuthorEna Parać
AuthorLovre Pedić
AuthorElvira Lazić-Mosler
Author's institutionCatholic University of Croatia
Author's institution(Sestre milosrdnice University Hospital Center)
Author's institutionUniversity of Zagreb
School of Dental Medicine
(Chair of Dermatovenerology)
Scientific / art field,
discipline and subdiscipline		BIOMEDICINE AND HEALTHCARE
Clinical Medical Sciences
Dermatovenerology
Abstract (english)
The epidermis serves many vital roles, including protecting the body from external influences and healing eventual injuries. It is maintained by an incredibly complex and perfectly coordinated keratinization process. In this process, desquamation is essential for the differentiation of epidermal basal progenitor cells into enucleated corneocytes, which subsequently desquamate through programmed death. Numerous factors control keratinocyte differentiation: epidermal growth factor, transforming growth factor-α, keratinocyte growth factor, interleukins IL-1-β and IL-6, elevated vitamin A levels, and changes in Ca2+ concentration. The backbone of the keratinocyte transformation process from mitotically active basal cells into fully differentiated, enucleated corneocytes is the expression of specific proteins and the creation of a Ca2+ and pH gradient at precise locations within the epidermis. Skin keratinization disorders (histologically characterized predominantly by dyskeratosis, parakeratosis, and hyperkeratosis) may be categorized into three groups: defects in the α-helical rod pattern, defects outside the α-helical rod domain, and disorders of keratin-associated proteins. Understanding the process of keratinization is essential for the pathogenesis of many dermatological diseases because improper desquamation and epidermopoiesis/keratinization (due to genetic mutations of factors or due to immune pathological processes) can lead to various conditions (ichthyoses, palmoplantar keratodermas, psoriasis, pityriasis rubra pilaris, epidermolytic hyperkeratosis, and others).
Keywords (english)
Languageenglish
Publication typeScientific paper - Review paper
Publication statusPublished
Peer reviewPeer review - international
Publication versionPublished version
Journal titleInternational Journal of Molecular Sciences
Numberingvol. 25, no. 1, 236
e-ISSN1422-0067
DOIhttps://doi.org/10.3390/ijms25010236
URN:NBNurn:nbn:hr:127:500792
Publication2023-12-23
Document URLhttps://www.mdpi.com/1422-0067/25/1/236
Type of resourceText
Access conditionsOpen access
Terms of useLicence Attribution-NonCommercial 4.0 International (CC BY-NC 4.0) icon
Created on2024-02-15 07:51:18