Vrste kvasnica u usnoj šupljini bolesnika zračenih u području glave i vrata

master's thesis

• Title (english): Oral cavity yeast-like species in head and neck irradiated patients
• Author: Katja Milatić
• Mentor: Ivan Alajbeg (mentor)
• Committee member: Ivan Alajbeg (predsjednik povjerenstva)
• Committee member: Goranka Prpić-Mehičić (član povjerenstva)
• Committee member: Vlaho Brailo (član povjerenstva)
• Granter: University of Zagreb; School of Dental Medicine; (Department of Oral Medicine); Zagreb
• Defense date and country: 2016-07-15, Croatia
• Scientific / art field, discipline and subdiscipline: BIOMEDICINE AND HEALTHCARE; Dental Medicine; Oral Medicine

Abstract

Kiruški liječeni pacijenti oboljeli od tumora glave i vrata najčešće su i zračeni
u adjuvantnoj terapiji.
Tijekom terapije zračenjem dolazi do promjena u pojavnosti kandidijaze i
promjeni vrsta kvasnica kod tih pacijenata u odnosu na nalaz prije i tri tjedna nakon
zračenja.
Od 25 ispitanika ove studije samo je 20% ispitanih imalo kandidijazu s dvije
vrste kandida (C.albicans i C. glabrata) u obrisku prije zračenja, a također i tri
tjedna nakon zračenja (C.albicans i C.krusei), a 36% ispitanika je imalo kandidijazu i
5 vrsta kvasnica uključujući i 4 vrste kandida tijekom zračenja.
Porast broja oboljelih od kandidijaze, pozitivnih obrisaka na gljive i broja
vrsta kvasnica tijekom zračenja bio je statistički značajan odnosno (p≤0,05).
Pojavnost kandide u ovoj skupini ispitanika oboljelih od malignih tumora
glave i vrata prije i nakon zračenja bila je za 30% manja od očekivane pojavnosti od
50%, koja se prema navodima u literaturi, može pronaći u zdravoj populaciji.
Značajno je da su svi s pozitivnim obriskom na gljive iz porodice kvasnica
imali i kandidijazu prije i tijekom zračenja, odnosno kod svih je kandida bila prisutna
ne kao saprofit nego isključivo patogen, zbog čega se može zaključiti je da je
nastavila biti patogen i tijekom zračenja neovisno o istodobnoj prisutnosti mukozitisa
u tih pacijenata.

Abstract (english)

Surgically treated patients with, head and neck cancer commonly receive
irradiation as an additional therapy.
During irradiation therapy, patients experience changes in the occurrence of
candidiasis and a change of isolated yeast-like species compared to findings before
and three weeks after finalization of irradiation therapy.
Out of 25 tested patients in this study, only 20% suffered from candidiasis
with two species of candidae (C. albicans and C. glabrata) before treatment and
three weeks after the finalization of the tratment (C. albicans and C. krusei), and
36% of them suffered from candidiasis and five different yeast-like species were
isolated (including four different Candida species) during the treatment.
Number of patients with candidiasis, number of positive oral smears, the
same as number of yeast like species isolated were all significantly increased during
the irradiation therapy (p≤0,05).
There was 30% less positive oral smears on yeast like species before and
three weeks after irradiation treatment in this group of patients with head and neck
cancer than 50% normaly expected in healthy population.
It is significant that all the patients with a positive oral smear on yeast-like
species also suffered from candidiasis before and after irradiation therapy, hence
among that patients candida was not saprophyt but exclusively pathogen. So, we can
conclude that even during the irradiation therapy candida continued to be a pathogen
regardless of mucositis also present at the time.

• Keywords: kandidijaza oralna; novotvorine glave i vrata; kvasnice; zračenje glave i vrata
• Keywords (english): candidiasis oral; head and neck neoplasms; yeasts; cranial irradiation
• Language: croatian
• URN:NBN: urn:nbn:hr:127:836912
• Study programme: Title: dental medicine; Study programme type: university; Study level: integrated undergraduate and graduate; Academic / professional title: doktor/doktorica dentalne medicine (doktor/doktorica dentalne medicine)
• Type of resource: Text
• File origin: Born digital
• Access conditions: Open access
• Created on: 2016-11-14 10:36:13