prikaz prve stranice dokumenta DNA Methylome Distinguishes Head and Neck Cancer from Potentially Malignant Oral Lesions and Healthy Oral Mucosa
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Scientific paper - Original scientific paper
DNA Methylome Distinguishes Head and Neck Cancer from Potentially Malignant Oral Lesions and Healthy Oral Mucosa
International Journal of Molecular Sciences, 21 (2020), 18; 6853. https://doi.org/10.3390/ijms21186853
Milutin Gašperov, Nina; Sabol, Ivan; Božinović, Ksenija; Dediol, Emil; Mravak-Stipetić, Marinka; Licastro, Danilo; Dal Monego, Simeone; Grce, Magdalena

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Milutin Gašperov, N., Sabol, I., Božinović, K., Dediol, E., Mravak Stipetić, M., Licastro, D. ... Grce, M. (2020). DNA Methylome Distinguishes Head and Neck Cancer from Potentially Malignant Oral Lesions and Healthy Oral Mucosa. International Journal of Molecular Sciences, 21. (18). doi: 10.3390/ijms21186853

Milutin Gašperov, Nina, et al. "DNA Methylome Distinguishes Head and Neck Cancer from Potentially Malignant Oral Lesions and Healthy Oral Mucosa." International Journal of Molecular Sciences, vol. 21, no. 18, 2020. https://doi.org/10.3390/ijms21186853

Milutin Gašperov, Nina, Ivan Sabol, Ksenija Božinović, Emil Dediol, Marinka Mravak Stipetić, Danilo Licastro, Simeone Dal Monego and Magdalena Grce. "DNA Methylome Distinguishes Head and Neck Cancer from Potentially Malignant Oral Lesions and Healthy Oral Mucosa." International Journal of Molecular Sciences 21, no. 18 (2020). https://doi.org/10.3390/ijms21186853

Milutin Gašperov, N., et al. (2020) 'DNA Methylome Distinguishes Head and Neck Cancer from Potentially Malignant Oral Lesions and Healthy Oral Mucosa', International Journal of Molecular Sciences, 21(18). doi: 10.3390/ijms21186853

Milutin Gašperov N, Sabol I, Božinović K, Dediol E, Mravak Stipetić M, Licastro D, and sur.. DNA Methylome Distinguishes Head and Neck Cancer from Potentially Malignant Oral Lesions and Healthy Oral Mucosa. International Journal of Molecular Sciences [Internet]. 2020 September 18 [cited 2024 April 17];21(18). doi: 10.3390/ijms21186853

N. Milutin Gašperov, et al., "DNA Methylome Distinguishes Head and Neck Cancer from Potentially Malignant Oral Lesions and Healthy Oral Mucosa", International Journal of Molecular Sciences, vol. 21, no. 18, September 2020. [Online]. Available at: https://urn.nsk.hr/urn:nbn:hr:127:688471. [Accessed: 17 April 2024]

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Metadata
Title (english)DNA Methylome Distinguishes Head and Neck Cancer from Potentially Malignant Oral Lesions and Healthy Oral Mucosa
AuthorNina Milutin Gašperov
AuthorIvan Sabol
AuthorKsenija Božinović
AuthorEmil Dediol
AuthorMarinka Mravak-Stipetić
AuthorDanilo Licastro
AuthorSimeone Dal Monego
AuthorMagdalena Grce
Author's institutionRuđer Bošković Institute
Author's institution(Zagreb University Hispital Center)
Author's institutionUniversity of Zagreb
School of Medicine
Scientific / art field,
discipline and subdiscipline		BIOMEDICINE AND HEALTHCARE
Dental Medicine
Abstract (english)
There is a strong need to find new, good biomarkers of head and neck squamous cell carcinoma (HNSCC) because of the bad prognoses and high mortality rates. The aim of this study was to identify the potential biomarkers in HNSCC that have differences in their DNA methylome and potentially premalignant oral lesions, in comparison to healthy oral mucosa. In this study, 32 oral samples were tested: nine healthy oral mucosae, 13 HNSCC, and 10 oral lesions for DNA methylation by the Infinium MethylationEPIC BeadChip. Our findings showed that a panel of genes significantly hypermethylated in their promoters or specific sites in HNSCC samples in comparison to healthy oral samples, which are mainly oncogenes, receptor, and transcription factor genes, or genes included in cell cycle, transformation, apoptosis, and autophagy. A group of hypomethylated genes in HNSCC, in comparison to healthy oral mucosa, are mainly involved in the host immune response and transcriptional regulation. The results also showed significant differences in gene methylation between HNSCC and potentially premalignant oral lesions, as well as differently methylated genes that discriminate between oral lesions and healthy mucosa. The given methylation panels point to novel potential biomarkers for early diagnostics of HNSCC, as well as potentially premalignant oral lesions.
Keywords (english)
Languageenglish
Publication typeScientific paper - Original scientific paper
Publication statusPublished
Peer reviewPeer review - international
Publication versionPublished version
Journal titleInternational Journal of Molecular Sciences
Numberingvol. 21, no. 18, 6853
e-ISSN1422-0067
DOIhttps://doi.org/10.3390/ijms21186853
URN:NBNurn:nbn:hr:127:688471
Publication2020-09-18
Document URLhttps://www.mdpi.com/1422-0067/21/18/6853
Type of resourceText
Access conditionsOpen access
Terms of useLicence Attribution 4.0 International (CC BY 4.0) icon
Created on2022-11-10 12:44:57