prikaz prve stranice dokumenta Comparison of Androgen Receptor, VEGF, HIF-1, Ki67 and MMP9 Expression between Non-Metastatic and Metastatic Stages in Stromal and Tumor Cells of Oral Squamous Cell Carcinoma
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Scientific paper - Original scientific paper
Comparison of Androgen Receptor, VEGF, HIF-1, Ki67 and MMP9 Expression between Non-Metastatic and Metastatic Stages in Stromal and Tumor Cells of Oral Squamous Cell Carcinoma
Life, 11 (2021), 4; 336. https://doi.org/10.3390/life11040336
Batelja-Vuletić, Lovorka; Tomasović-Lončarić, Cedna; Ceppi, Marcello; Bruzzone, Marco; Fučić, Aleksandra; Krstanac, Karolina; Boras Vučićević, Vanja

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Batelja Vuletić, L., Tomasović Lončarić, C., Ceppi, M., Bruzzone, M., Fučić, A., Krstanac, K. & Boras Vučićević, V. (2021). Comparison of Androgen Receptor, VEGF, HIF-1, Ki67 and MMP9 Expression between Non-Metastatic and Metastatic Stages in Stromal and Tumor Cells of Oral Squamous Cell Carcinoma. Life, 11. (4). doi: 10.3390/life11040336

Batelja Vuletić, Lovorka, et al. "Comparison of Androgen Receptor, VEGF, HIF-1, Ki67 and MMP9 Expression between Non-Metastatic and Metastatic Stages in Stromal and Tumor Cells of Oral Squamous Cell Carcinoma." Life, vol. 11, no. 4, 2021. https://doi.org/10.3390/life11040336

Batelja Vuletić, Lovorka, Cedna Tomasović Lončarić, Marcello Ceppi, Marco Bruzzone, Aleksandra Fučić, Karolina Krstanac and Vanja Boras Vučićević. "Comparison of Androgen Receptor, VEGF, HIF-1, Ki67 and MMP9 Expression between Non-Metastatic and Metastatic Stages in Stromal and Tumor Cells of Oral Squamous Cell Carcinoma." Life 11, no. 4 (2021). https://doi.org/10.3390/life11040336

Batelja Vuletić, L., et al. (2021) 'Comparison of Androgen Receptor, VEGF, HIF-1, Ki67 and MMP9 Expression between Non-Metastatic and Metastatic Stages in Stromal and Tumor Cells of Oral Squamous Cell Carcinoma', Life, 11(4). doi: 10.3390/life11040336

Batelja Vuletić L, Tomasović Lončarić C, Ceppi M, Bruzzone M, Fučić A, Krstanac K, and sur.. Comparison of Androgen Receptor, VEGF, HIF-1, Ki67 and MMP9 Expression between Non-Metastatic and Metastatic Stages in Stromal and Tumor Cells of Oral Squamous Cell Carcinoma. Life [Internet]. 2021 April 10 [cited 2024 April 21];11(4). doi: 10.3390/life11040336

L. Batelja Vuletić, et al., "Comparison of Androgen Receptor, VEGF, HIF-1, Ki67 and MMP9 Expression between Non-Metastatic and Metastatic Stages in Stromal and Tumor Cells of Oral Squamous Cell Carcinoma", Life, vol. 11, no. 4, April 2021. [Online]. Available at: https://urn.nsk.hr/urn:nbn:hr:127:914613. [Accessed: 21 April 2024]

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Title (english)Comparison of Androgen Receptor, VEGF, HIF-1, Ki67 and MMP9 Expression between Non-Metastatic and Metastatic Stages in Stromal and Tumor Cells of Oral Squamous Cell Carcinoma
AuthorLovorka Batelja-Vuletić
AuthorCedna Tomasović-Lončarić
AuthorMarcello Ceppi
AuthorMarco Bruzzone
AuthorAleksandra Fučić
AuthorKarolina Krstanac
AuthorVanja Boras Vučićević
Author's institutionUniversity of Zagreb
School of Medicine
Author's institutionUniversity of Zagreb
School of Dental Medicine
Scientific / art field,
discipline and subdiscipline		BIOMEDICINE AND HEALTHCARE
Dental Medicine
Abstract (english)
Objectives: Oral squamous cell carcinoma (OSCC) is the most common oral malignancy with low survival as it is very often diagnosed at an advanced stage, which is why the accurate profiling of the tumor is essential. The aim of this study was to, for the first time, compare in OSCC the frequency of AR, VEGF, MMP9, HiF1beta and Ki67 between the non-metastatic and metastatic disease. Materials and Methods: In the study, 96 non-metastatic and 91 metastatic OSCC patients were analysed for AR, VEGF, MMP9, HiF1beta and Ki67 levels by immunohistochemistry. Results: All of the tested biomarkers significantly differed between non-metastatic and metastatic disease. A significant association was found between >/=20% AR positive epithelium cells in cytoplasm, Ki67 and VEGF in cancer stroma. Ki67, HiF1beta, VEGF and MMP9 were significantly associated with TNM stages. Conclusion: Our results show for the first time an interplay between AR, VEGF, MMP9, HiF1beta and Ki67 in OSCC which may contribute to better diagnostics and therapy selection.
Keywords (english)
Languageenglish
Publication typeScientific paper - Original scientific paper
Publication statusPublished
Peer reviewPeer review - international
Publication versionPublished version
Journal titleLife
Numberingvol. 11, no. 4, 336
e-ISSN2075-1729
DOIhttps://doi.org/10.3390/life11040336
URN:NBNurn:nbn:hr:127:914613
Publication2021-04-10
Document URLhttps://www.mdpi.com/2075-1729/11/4/336
Type of resourceText
Access conditionsOpen access
Terms of useLicence Attribution 4.0 International (CC BY 4.0) icon
Created on2022-11-10 11:16:04