Suvremena klasifikacija odontogenih lezija

master's thesis

• Title (english): Modern classification of odontogenic lesions
• Author: Lucija Kuterovac
• Mentor: Davor Brajdić (mentor)
• Committee member: Davor Brajdić (predsjednik povjerenstva)
• Committee member: Josip Biočić (član povjerenstva)
• Committee member: Ivan Salarić (član povjerenstva)
• Granter: University of Zagreb; School of Dental Medicine; (Department of Oral Surgery); Zagreb
• Defense date and country: 2022-09-23, Croatia
• Scientific / art field, discipline and subdiscipline: BIOMEDICINE AND HEALTHCARE; Dental Medicine; Oral Surgery

Abstract

Postoje mnogobrojne patološke promjene koje mogu zahvatiti područje maksile i
mandibule, a neke od njih su i lezije odontogenog porijekla. One podrazumijevaju vrlo
heterogenu skupinu lezija koje potječu od epitelnog i/ili mezenhimalnog odontogenog tkiva.
Pojavljuju se u širokom spektru lezija koje mogu biti u obliku hamartoma i cista, pa sve do
benignih i malignih neoplastičnih tvorbi. Kako bi se olakšao postupak postavljanja pravilne
dijagnoze, a samim time i procjene prognoze i odabir načina liječenja, postojala je potreba da
se lezije odontogenog porijekla sistematiziraju, organiziraju i pravilno klasificiraju. Tek je
1972. godine pod okriljem Svjetske zdravstvene organizacije (SZO) izdano 1. izdanje
međunarodne klasifikacije odontogenih lezija, čime započinje era sve većeg interesa za ovo
područje. Pristizanjem novih molekularnobioloških i imunohistokemijskih metodologija, ova
se klasifikacija vrlo brzo obnavljala i obogaćivala novim spoznajama, što je posljedično
rezultiralo sa sveukupno 5 izdanja WHO (World Health Organizatoin) klasifikacije
odontogenih lezija. Cilj je svake od njih bio pružiti bolji uvid u patološke promjene do tada
nejasno opisane te pridonijeti boljem razumijevanju istih. U posljednje dvije klasifikacije iz
2017. i 2022. veliki je naglasak stavljen na kliničke značajke, molekularnu podlogu i prirodu
lezija odontogenog porijekla, a ne samo na njihove histološke karakteristike.

Abstract (english)

There are numerous pathological changes that can affect the area of the maxilla and the
mandible, some of which are lesions of odontogenic origin. That is a very heterogeneous
group of lesions originating from epithelial and/or mesenchymal odontogenic tissue. They can
take various forms, from hamartomas and cysts to benign and malignant neoplastic
formations. In order to facilitate the process of proper diagnosis and thus of giving a
prognosis and of choosing treatment, a need arose to systematise, organise and properly
classify lesions of odontogenic origin. It was only in 1972 that the 1st edition of the
international classification of odontogenic lesions was published under the auspices of the
World Health Organization (WHO), starting an era of increasing interest in this area. With
new molecular biological and immunohistochemical methodologies, this classification has
been rapidly renewed and enriched with new knowledge, which resulted in a total of 5
editions of WHO classifications of odontogenic lesions. The goal of each of them was to
provide a better insight into the vaguely described pathological changes and to contribute to a
better understanding of the changes. In the last two classifications, from 2017 and 2022, great
emphasis was placed on clinical features, molecular basis, and the nature of lesions of
odontogenic origin, and not just on their histological features.

• Keywords: odontogeni tumori; odontogene ciste
• Keywords (english): Odontogenic Tumors; Odontogenic Cysts
• Language: croatian
• URN:NBN: urn:nbn:hr:127:456082
• Study programme: Title: dental medicine; Study programme type: university; Study level: integrated undergraduate and graduate; Academic / professional title: doktor/doktorica dentalne medicine (doktor/doktorica dentalne medicine)
• Type of resource: Text
• File origin: Born digital
• Access conditions: Open access
• Created on: 2022-11-10 08:44:52