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Scientific paper - Original scientific paper
Distribution of Pathogens and Predictive Values of Biomarkers of Inflammatory Response at ICU Admission on Outcomes of Critically Ill COVID-19 Patients with Bacterial Superinfections—Observations from National COVID-19 Hospital in Croatia
Diagnostics, 12 (2022), 9; 2069. https://doi.org/10.3390/diagnostics12092069
Ćurčić, Maja; Tarle, Marko; Almahariq, Hani; Hleb, Sonja; Havaš, Juraj; Pražetina, Marko; Lasić, Hrvoje; Dolenc, Emil; Kukoč, Andrea; Mihelčić, Antonija; Miko, Ivan; Romić, Andrea; Tipura, Danijela; Drmić, Željka; Čučković, Marcela; Blagaj, Vanja; Lukšić, Ivica; Peršec, Jasminka; Šribar, Andrej More authors...

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Ćurčić, M., Tarle, M., Almahariq, H., Hleb, S., Havaš, J., Pražetina, M. ... Šribar, A. (2022). Distribution of Pathogens and Predictive Values of Biomarkers of Inflammatory Response at ICU Admission on Outcomes of Critically Ill COVID-19 Patients with Bacterial Superinfections—Observations from National COVID-19 Hospital in Croatia. Diagnostics, 12. (9). doi: 10.3390/diagnostics12092069

Ćurčić, Maja, et al. "Distribution of Pathogens and Predictive Values of Biomarkers of Inflammatory Response at ICU Admission on Outcomes of Critically Ill COVID-19 Patients with Bacterial Superinfections—Observations from National COVID-19 Hospital in Croatia." Diagnostics, vol. 12, no. 9, 2022. https://doi.org/10.3390/diagnostics12092069

Ćurčić, Maja, Marko Tarle, Hani Almahariq, Sonja Hleb, Juraj Havaš, Marko Pražetina, Hrvoje Lasić, et al. "Distribution of Pathogens and Predictive Values of Biomarkers of Inflammatory Response at ICU Admission on Outcomes of Critically Ill COVID-19 Patients with Bacterial Superinfections—Observations from National COVID-19 Hospital in Croatia." Diagnostics 12, no. 9 (2022). https://doi.org/10.3390/diagnostics12092069

Ćurčić, M., et al. (2022) 'Distribution of Pathogens and Predictive Values of Biomarkers of Inflammatory Response at ICU Admission on Outcomes of Critically Ill COVID-19 Patients with Bacterial Superinfections—Observations from National COVID-19 Hospital in Croatia', Diagnostics, 12(9). doi: 10.3390/diagnostics12092069

Ćurčić M, Tarle M, Almahariq H, Hleb S, Havaš J, Pražetina M, and sur.. Distribution of Pathogens and Predictive Values of Biomarkers of Inflammatory Response at ICU Admission on Outcomes of Critically Ill COVID-19 Patients with Bacterial Superinfections—Observations from National COVID-19 Hospital in Croatia. Diagnostics [Internet]. 2022 August 26 [cited 2025 January 19];12(9). doi: 10.3390/diagnostics12092069

M. Ćurčić, et al., "Distribution of Pathogens and Predictive Values of Biomarkers of Inflammatory Response at ICU Admission on Outcomes of Critically Ill COVID-19 Patients with Bacterial Superinfections—Observations from National COVID-19 Hospital in Croatia", Diagnostics, vol. 12, no. 9, August 2022. [Online]. Available at: https://urn.nsk.hr/urn:nbn:hr:127:979664. [Accessed: 19 January 2025]

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Metadata
Title (english)Distribution of Pathogens and Predictive Values of Biomarkers of Inflammatory Response at ICU Admission on Outcomes of Critically Ill COVID-19 Patients with Bacterial Superinfections—Observations from National COVID-19 Hospital in Croatia
AuthorMaja Ćurčić
AuthorMarko Tarle
AuthorHani Almahariq
AuthorSonja Hleb
AuthorJuraj Havaš
AuthorMarko Pražetina
AuthorHrvoje Lasić
AuthorEmil Dolenc
AuthorAndrea Kukoč
AuthorAntonija Mihelčić
AuthorIvan Miko
AuthorAndrea Romić
AuthorDanijela Tipura
AuthorŽeljka Drmić
AuthorMarcela Čučković
AuthorVanja Blagaj
AuthorIvica Lukšić
AuthorJasminka Peršec
AuthorAndrej Šribar
Author's institutionUniversity of Zagreb
School of Dental Medicine
Scientific / art field,
discipline and subdiscipline		BIOMEDICINE AND HEALTHCARE
Dental Medicine
Abstract (english)
Background: Superinfections contribute to mortality and length of stay in critically ill COVID-19 patients. The aim of this study was to determine the incidence and pathogen distribution of bacterial and fungal superinfections of the lower respiratory tract (LRTI), urinary tract (UTI) and bloodstream (BSI) and to determine the predictive value of biomarkers of inflammatory response on their ICU survival rates. Methods: A retrospective observational study that included critically ill COVID-19 patients treated during an 11-month period in a Croatian national COVID-19 hospital was performed. Clinical and diagnostic data were analyzed according to the origin of superinfection, and multivariate regression analysis was performed to determine the predictive values of biomarkers of inflammation on their survival rates. Results: 55.3% critically ill COVID-19 patients developed bacterial or fungal superinfections, and LRTI were most common, followed by BSI and UTI. Multidrug-resistant pathogens were the most common causes of LRTI and BSI, while Enterococcus faecalis was the most common pathogen causing UTI. Serum ferritin and neutrophil count were associated with decreased chances of survival in patients with LRTI, and patients with multidrug-resistant isolates had significantly higher mortality rates, coupled with longer ICU stays. Conclusion: The incidence of superinfections in critically ill COVID-19 patients was 55.3%, and multidrug-resistant pathogens were dominant. Elevated ferritin levels and neutrophilia at ICU admission were associated with increased ICU mortality in patients with positive LRTI.
Keywords (english)
Languageenglish
Publication typeScientific paper - Original scientific paper
Publication statusPublished
Peer reviewPeer review - international
Publication versionPublished version
Journal titleDiagnostics
Numberingvol. 12, no. 9, 2069
e-ISSN2075-4418
DOIhttps://doi.org/10.3390/diagnostics12092069
URN:NBNurn:nbn:hr:127:979664
Publication2022-08-26
Document URLhttps://www.mdpi.com/2075-4418/12/9/2069
Type of resourceText
Access conditionsOpen access
Terms of useLicence Attribution 4.0 International (CC BY 4.0) icon
Created on2022-10-26 08:00:16