Suvremeni pristup otvorenim vestibuloplastikama

master's thesis

• Title (english): Contemporary approach to open vestibuloplastics
• Author: Luka Šimunović
• Mentor: Irina Filipović-Zore (mentor)
• Committee member: Irina Filipović-Zore (predsjednik povjerenstva)
• Committee member: Tomislav Katanec (član povjerenstva)
• Committee member: Ana Badovinac (član povjerenstva)
• Granter: University of Zagreb; School of Dental Medicine; (Department of Oral Surgery); Zagreb
• Defense date and country: 2022-07-01, Croatia
• Scientific / art field, discipline and subdiscipline: BIOMEDICINE AND HEALTHCARE; Dental Medicine; Oral Surgery

Abstract

Pretprotetska kirurgija definira se kao kirurški zahvat dizajniran za olakšavanje izrade proteza
ili za poboljšanje prognoze protetske opskrbe. Koštano preoblikovanje alveolarnog grebena je
doživotan proces kontinuiranog gubitka alveolarne kosti te predstavlja ozbiljan i čest problem,
posebice kod starijih osoba. Postoji velik broj operativnih metoda plastike vestibularne ili
lingvalne brazde s ciljem otklanjanja posljedica ravnomjerne atrofije alveolarnog nastavka i
stvaranja povoljnih uvjeta za izradu suficijentnog mobilnog nadomjestka.
PRF kako mu samo ime kaže “platelet-rich fibrin”, odnosno trombocitima bogat fibrin često
je korišten u regenerativnim zahvatima u dentalnoj medicini. Prisutnost PRF fibrinske mrežice
na početku cijeljenja rane stimulira angiogenezu u području rane. Ranijim istraživanjima
pokazalo se kako se tijekom tjedan dana iz PRF-a otpušta čak 6 faktora rasta stalne
koncentracije. Faktori rasta su endogene signalne molekule koje igraju važnu ulogu u
promicanju stanične diferencijacije i diobe stanica te na taj način reguliraju stanične odgovore
za proces cijeljenja rane. Glavne prednosti rada s PRF-om su jednostavnost pripravka preparata,
dostupnost svim pacijentima te minimalna trauma.
Nadalje, kako bi se smanjili nedostaci konvencionalnih zahvata vestibuloplastike, PRF
membrana može se koristiti za prekrivanje izloženog područja. Stoga ne bi bilo potrebe za
daljnjim uzimanjem kožnog ili mukoznog transplantata. Osim toga, epitelizacija rane je brža te
lakoća primjene ovog prirodnog biomaterijala može u konačnici povećati njegovu prihvaćenost
među kirurzima i pacijentima, dok pacijentima ostavlja manje komplikacija nakon operacije.

Abstract (english)

Pre-prosthetic surgery is defined as a surgical procedure designed to facilitate the production
of prostheses or to improve the prognosis of prosthetic supply. Bone remodeling of the alveolar
ridge is a lifelong process, while continuous loss of alveolar bone is a serious and common
problem, especially in the elderly. There are several operative methods of vestibular or lingual
plastic surgery to eliminate the consequences of uniform atrophy of the alveolar process and
create favorable conditions for the production of a removable denture.
PRF as its name suggests "platelet-rich fibrin", is often used in regenerative procedures in
dentistry. The presence of PRF fibrin mesh at the beginning of wound healing stimulates
angiogenesis in the wound area. Previous research has shown that during the week, as many as
6 growth factors of constant concentration are released from the PRF. Growth factors are
endogenous signaling molecules that play an important role in promoting cell differentiation
and cell division and thus regulate cellular responses to the wound healing process. The main
advantages of working with PRF are the simplicity of preparation, availability to all patients
and minimal trauma.
Furthermore, in order to reduce the disadvantages of conventional vestibuloplasty procedures,
a PRF membrane can be used to cover the exposed area. Therefore, there would be no need to
take a skin or mucosal transplant. In addition, wound epithelialization is more rapid, while easy
application of this natural biomaterial can ultimately increase its acceptance among surgeons
and patients, while patients have fewer complications after surgery.

• Keywords: pretprotetska oralna kirurgija; vestibuloplastika
• Keywords (english): Preprosthetic Oral Surgery; Vestibuloplasty
• Language: croatian
• URN:NBN: urn:nbn:hr:127:276206
• Study programme: Title: dental medicine; Study programme type: university; Study level: integrated undergraduate and graduate; Academic / professional title: doktor/doktorica dentalne medicine (doktor/doktorica dentalne medicine)
• Type of resource: Text
• File origin: Born digital
• Access conditions: Embargoed access; Embargo expiration date: 2026-11-08
• Created on: 2022-10-19 12:21:38