Uloga doktora dentalne medicine u dijagnostici i liječenju Sjögrenovog sindroma

master's thesis

• Title (english): The role of dentist in the diagnosis and treatment of Sjögren's syndrome
• Author: Nikolina Horvatek
• Mentor: Ivana Škrinjar (mentor)
• Committee member: Vlaho Brailo (predsjednik povjerenstva)
• Committee member: Ana Andabak Rogulj (član povjerenstva)
• Committee member: Ivana Škrinjar (član povjerenstva)
• Granter: University of Zagreb; School of Dental Medicine; (Department of Oral Medicine); Zagreb
• Defense date and country: 2022-06-23, Croatia
• Scientific / art field, discipline and subdiscipline: BIOMEDICINE AND HEALTHCARE; Dental Medicine

Abstract

Sjögrenov sindrom sustavna je kronična idiopatska autoimuna bolest koja najčešće zahvaća
ţene u postmenopauzi, a kao glavni simptomi bolesti navode se suhoća očiju i usta.
Inflitracija egzokrinih ţlijezda limfocitima T uzrokuje tkivno oštećenje te se posljedično javlja
suhoća koţe i sluznica. Osim koţe i sluznica, bolešću mogu biti zahvaćeni i ostali organski
sustavi. U dijagnostici Sjögrenovog sindroma potreban je multidisciplinarni pristup.
Dijagnoza se postavlja na temelju specifičnih kriterija koji uključuju subjektivne simptome i
objektivne znakove bolesti. Prisutnim simptomima i znakovima pridodaje se odreĎen broj
bodova, a zatim se bodovi zbrajaju i potvrĎuju dijagnozu. Fokalni limfocitni sijaloadenitis
labijalnih ţlijezda slinovnica te pozitivan serumski nalaz anti-SSA potvrĎuju dijagnozu.
Doktor dentalne medicine posljedice suhoće usta liječi simptomatski. Cilj liječenja je
ublaţavanje simptoma i prevencija posljedica suhoće usta. S obzirom na to da dolazi do
ireverzibilnog oštećenja ţljezdanog parenhima, sekrecija sline ne moţe se vratiti u normalne
vrijednosti prije početka bolesti te je potrebna cijeloţivotna terapija i prilagodba ţivotnih
navika

Abstract (english)

Sjögren's syndrome is a systemic chronic idiopathic autoimmune disease which typically
affects postmenopausal women. The main symptoms of the disease are dryness of the eyes
and mouth. Infiltration of exocrine glands by T-lymphocytes causes damage to the tissue
which leads to the dryness of the skin and mucous membrane. In addition to the skin and
mucous membrane, this diagnostics requires a multidisciplinary approach. Diagnosis is based
on specific criteria which include subjective symptoms and objective signs of the disease. The
number of points is attached to each present sign and symptom, after which the points are
added up and the diagnosis is confirmed. Focal lymphocytic sialoadenitis of labial salivary
glands and positive anti-SSA serum results confirm the diagnosis. Dental medicine
practitioner treats the consequences of dry mouth symptomatically. The purpose of the
treatment is to ease the symptoms and prevent the consequences of dry mouth. Considering
the irreversible damage of the glandular parenchyma, saliva secretion cannot be reversed to
normal values which were present prior to the disease, so lifelong therapy and lifestyle
changes are needed.

• Keywords: idiopatska autoimuna bolest; suhoća očiju i usta; tkivno oštećenje; specifični kriteriji; simptomatsko liječenje; prevencija
• Keywords (english): idiopathic autoimmune disease; dryness of the eyes and mouth; damage to the tissue; specific criteria; treats symptomatically; prevent the consequences of dry mouth
• Language: croatian
• URN:NBN: urn:nbn:hr:127:219638
• Study programme: Title: dental medicine; Study programme type: university; Study level: integrated undergraduate and graduate; Academic / professional title: doktor/doktorica dentalne medicine (doktor/doktorica dentalne medicine)
• Type of resource: Text
• File origin: Born digital
• Access conditions: Open access
• Created on: 2022-10-14 11:19:27