Mehanizmi resorpcije kosti kod parodontitisa

master's thesis

• Title (english): Mechanisms of bone resorption in periodontitis
• Author: Mislav Golubić
• Mentor: Ivan Puhar (mentor)
• Committee member: Ivan Puhar (predsjednik povjerenstva)
• Committee member: Božana Lončar Brzak (član povjerenstva)
• Committee member: Samir Čimić (član povjerenstva)
• Granter: University of Zagreb; School of Dental Medicine; (Department of Periodontology); Zagreb
• Defense date and country: 2022-07-15, Croatia
• Scientific / art field, discipline and subdiscipline: BIOMEDICINE AND HEALTHCARE; Dental Medicine; Periodontology

Abstract

Parodontitis je upalna bolest koja zahvaća potporna tkiva zuba. Napredovanjem bolesti dolazi
do redukcije razine kosti i stabilnosti zuba u alveoli što rezultira gubitkom zuba. Nekada se
smatralo da bakterije uzrokuju destrukciju tkiva, no danas se zna da je to uravnoteženi
mehanizam između biofilma koji inducira imunološki sustav domaćina na eliminaciju toga
patogena. Kako su bakterije uklopljene u biofilm zaštićene od brojnih stanica obrane koje ne
mogu prodrijeti u njega, imunološki sustav ne suprimira imunološki odgovor, nego nastaje
kronična upala koja za posljedicu ima velik gubitak parodontnih tkiva.

Abstract (english)

Periodontitis is an inflammatory disease that affects tooth-supporting tissues. That progression
of the disease includes a reduction of bone hight and tooth stability in alveolus, which leads to
tooth loss. Not too long ago, it was thought that bacteria are the main cause of tissue destruction,
but as we know today, inflammatory cells play an important role in the destruction since biofilm
stimulate the host's immune system to eliminate pathogens. As bacteria are protected in the
biofilm that is out of reach for many immunologic cells, the immune system does not suppress
the immune response. It causes chronic inflammation with the consequence of significat
periodontal tissue loss.

• Keywords: parodontitis; gubitak alveolarne kosti; imunitet; gubitak zuba
• Keywords (english): periodontitis; alveolar bone loss; immunity; tooth loss
• Language: croatian
• URN:NBN: urn:nbn:hr:127:848892
• Study programme: Title: dental medicine; Study programme type: university; Study level: integrated undergraduate and graduate; Academic / professional title: doktor/doktorica dentalne medicine (doktor/doktorica dentalne medicine)
• Type of resource: Text
• File origin: Born digital
• Access conditions: Access restricted to students and staff of home institution
• Created on: 2022-10-11 11:54:12