Specifičnosti melanoma glave i vrata

master's thesis

• Title (english): Specificity of head and neck malignant melanoma
• Author: Ksenija Palaić
• Mentor: Davor Vagić (mentor)
• Committee member: Davor Vagić
• Committee member: Robert Trotić
• Committee member: Goran Geber
• Granter: University of Zagreb; School of Dental Medicine; (Chair of Otorhynolaringology); Zagreb
• Defense date and country: 2015-07-08, Croatia
• Scientific / art field, discipline and subdiscipline: BIOMEDICINE AND HEALTHCARE; Dental Medicine; Oral Medicine

Abstract

Melanom je zloćudni tumor melanocita. Nalazi se pretežno na koži, ali se može naći i u sluznici. Primarni uzrok melanoma je djelovanje ultraljubičastog svjetla. Rani znakovi melanoma su promjene u veličini, boji i obliku postojećih madeža. Potvrda kliničke dijagnoze postiže se pomoću biopsije kože. Melanomi se obično šire u limfne čvorove, u područje oko tumora. Biopsija sentinel limfnog čvora je indicirana za patološko stupnjevanje regionalnog limfnog čvora. Tradicionalni TNM (tumor – limfni čvor – metastaza) klasifikacijski sustav klasificira melanom na temelju njegovih karakteristika. Faze I i II obuhvaćaju lokalizirani primarni melanom. U fazi III postoje metastaze na jednom regionalnom limfnom čvoru. Faza IV je udaljena metastatska bolest. Osnovna terapija melanoma je kirurška ekscizija s odgovarajućim kirurškim marginama. Često se to radi širokom lokalnom ekscizijom s 1 - 2 cm margine. Ako su limfni čvorovi pozitivni, izvest će se radikalna disekcija limfnog čvora.

Abstract (english)

Melanoma is a malignancy of melanocytes located predominantly in the skin but also found in mucous membranes. The primary cause of malignant melanoma is ultraviolet light. Early signs of melanoma are the changes of size, colour and shape of the existing moles. Confirmation of the clinical diagnosis is done with a skin biopsy. Melanomas usually spread to the lymph nodes in the area of the tumour. Sentinel lymph node biopsy is generally indicated for pathologic staging of the regional lymph node. Traditional TNM (tumour – node - metastasis) classification system classifies melanomas on the basis of their characteristic. Stage I and II are localized primary melanoma. In stage III, there are metastases to single regional lymph node. Stage IV is the distant metastatic disease. Basic therapy of malignant melanoma is surgical excision with the adequate surgical margins. This is often done by a wide local excision with 1 to 2 cm margins. If a lymph node is positive, a radical lymph node dissection will often be performed.

• Keywords: biopsija sentinel limfnog čvora
• Keywords (english): sentinel lymph node biopsy
• Language: croatian
• URN:NBN: urn:nbn:hr:127:824728
• Study programme: Title: dental medicine; Study programme type: university; Study level: integrated undergraduate and graduate; Academic / professional title: doktor/doktorica dentalne medicine (doktor/doktorica dentalne medicine)
• Type of resource: Text
• File origin: Born digital
• Access conditions: Open access
• Created on: 2016-04-06 11:54:46