Modulacija odgovora domaćina na parodontnu infekciju

master's thesis

• Title (english): Host moduilation therapy
• Author: Ivona Kandić
• Mentor: Ivan Puhar (mentor)
• Committee member: Ivan Puhar (predsjednik povjerenstva)
• Committee member: Domagoj Vražić (član povjerenstva)
• Committee member: Darije Plančak (član povjerenstva)
• Granter: University of Zagreb; School of Dental Medicine; (Department of Periodontology); Zagreb
• Defense date and country: 2020-09-17, Croatia
• Scientific / art field, discipline and subdiscipline: BIOMEDICINE AND HEALTHCARE; Dental Medicine

Abstract

Pojam modulacija odgovora domaćina označava promjenu funkcije ili odgovora organizma na
kemijski ili fizikalni podražaj. Upala je fiziološki odgovor na ozljedu ili traumu kojim domaćin
nastoji ukloniti mikroorganizme iz inficiranog tkiva da bi se stvorili povoljni uvjeti za cijeljenje
i povrat funkcije tkiva. Produljen ili prekomjeran upalni odgovor domaćina oštećuje tkivo te
naposljetku rezultira pojavom bolesti. Modulacija odgovora domaćina na parodontnu infekciju
je pomoćna (adjuvantna) metoda parodontološke terapije. Terapijom se ne blokiraju normalni
mehanizmi obrane domaćina, već se ublažava prekomjeran upalni odgovor, čime se
uspostavljaju povoljni uvjeti za cijeljenje rane i postizanje parodontnog zdravlja. Svrha je
uspostaviti zdravu ravnotežu između proupalnih, destruktivnih čimbenika i protuupalnih,
zaštitinih mehanizama. Doksiciklin se u subantimikrobnoj dozi od 20 mg pokazao kao
učinkovita adjuvantna metoda liječenja parodontitisa koja u kombinaciji s nekirurškom
terapijom dovodi do statistički značajnog dobitka pričvrstka i smanjenja dubine sondiranja.
Periostat® je jedini komercijalno dostupan preparat za liječenje parodontitisa koji se
primjenjuje sistemski i odobren je od strane FDA-a (eng. U.S. Food and Drug Administration)
i ADA-e (eng. American Dental Association). Potrebno je provesti daljnja laboratorijska i
klinička istraživanja kako bi se dokazala korist upotrebe ostalih potencijalno modulirajućih
agensa u kliničkoj praksi. Razvojem novih modulirajućih agensa omogućit će se upotreba
dodatnih sredstava kojima se postiže poboljšan i predvidljiv odgovor domaćina na nekiruršku i
kiruršku terapiju parodontitisa.

Abstract (english)

The term host modulation is the alteration of function or status of organism in response to a
stimulus or an altered chemical or physical environment. Inflammation is a physiological
response to trauma or injury by which the host seeks to remove microorganisms from infected
tissues to create favourable condition for tissue healing and restoration of tissue function.
Prolonged or excessive inflammatory response of the host damages the tissue and eventually
results in the appearance of the disease. Host modulation (with chemotherapeutic agents or
drugs) is an adjunctive therapeutic option for the management of periodontal disease. The
therapy doesn't block normal defence mechanisms of the host, but alleviates the excessive
inflammatory response to enhance the opportunities for wound healing and periodontal
stability. The purpose of host modulation therapy is to restore a healthy balance between proinflammatory or destructive mediators and anti-inflammatory or protective mechanisms.
Doxycycline at a sub-antimicrobial dose of 20 mg has been indicated as an effective adjunctive
method of treating periodontitis which in combination with non-surgical therapy leads to a
statistically significant attachment gain and a reduction in probing depth. Periostat® is the only
commercially available host modulation agent for the treatment of periodontitis that is
administered systemically and is approved by the U.S. Food and Drug Administration (FDA)
and American Dental Association (ADA). Further laboratory and clinical research is needed to
demonstrate the benefit of using other potentially modulating agents in clinical practice. The
development of new host modulating agents will enable the use of additional agents that achieve
an improved and predictable host response to non-surgical and surgical therapy of periodontitis.

• Keywords: parodontitis; upala; Doksiciklin
• Keywords (english): Periodontitis; Inflammation; Doxycycline
• Language: croatian
• URN:NBN: urn:nbn:hr:127:031687
• Study programme: Title: dental medicine; Study programme type: university; Study level: integrated undergraduate and graduate; Academic / professional title: doktor/doktorica dentalne medicine (doktor/doktorica dentalne medicine)
• Type of resource: Text
• File origin: Born digital
• Access conditions: Open access
• Created on: 2021-01-19 11:33:37