Dijagnostika i liječenje premalignih lezija usne šupljine

master's thesis

• Title (english): Diagnostics and treatmen of premalignal lesinos in oral cavity
• Author: Hrvoje Ivanković
• Mentor: Davor Vagić (mentor)
• Committee member: Davor Vagić (predsjednik povjerenstva)
• Committee member: Robert Trotić (član povjerenstva)
• Committee member: Goran Geber (član povjerenstva)
• Granter: University of Zagreb; School of Dental Medicine; (Chair of Otorhynolaringology); Zagreb
• Defense date and country: 2020-07-03, Croatia
• Scientific / art field, discipline and subdiscipline: BIOMEDICINE AND HEALTHCARE; Clinical Medical Sciences; Otorhinolaryngology

Abstract

Premaligne lezije usne šupljine promjene su oralne sluznice koje imaju mogućnost zloćudne preobrazbe u oralni karcinom. Uključuju leukoplakiju, eritroplakiju, oralni lichen planus i aktinički cheilitis. Leukoplakija je naziv za bijelu promjenu na oralnoj sluznici koju nije moguće svrstati među druge oralne promjene i koja se ne može ukloniti struganjem. Razlikuju se nekoliko oblika kao što su homogena, nehomogena i vlasasta leukoplakija. Poseban je oblik kandidijalna leukoplakija nastala infekcijom gljivice Candida albicans. Eritroplakija je naziv za leziju usne šupljine crvene boje izrazito velikog potencijala za malignu transformaciju. Oralni lichen planus naziv je za kroničnu mukokutanu autoimunu bolest oralne sluznice koja se klinički može primijetiti u šest različitih oblika: papilarni, retikularni, plakozni, atrofični, erozivni i bulozni. Atrofični i erozivni oblici imaju veći rizik od zloćudne transformacije u usporedbi s drugima. Aktinički cheilitis upalna je promjena u području usnice nastala kao posljedica prekomjerne izloženosti ultraljubičastim (UV) zrakama. Dijagnostika premalignih lezija uključuje detaljno provođenje anamneze i kliničkog pregleda, oralno-laboratorijske testove, laboratorijske pretrage i toluidinski test. Pravilno postavljena dijagnoza omogućuje pravilan izbor terapije. Liječenje uključuje redovito praćenje napretka lezije, nekiruršku terapiju medikamentoznim preparatima i kirurško uklanjanje. Uloga je doktora dentalne medicine pravodobno otkrivanje i zbrinjavanje lezija te sprječavanje mogućeg nastanka oralnog karcinoma koji bitno mijenja kvalitetu života bolesnika.

Abstract (english)

Premalignant lesions of the oral cavity are changes in the oral mucosa that have the potential for malignant transformation into oral cancer. These include leukoplakia, erythroplakia, oral lichen planus and actinic cheilitis. Leukoplakia is the name for a white change on the oral mucosa that cannot be classified among other oral changes and that cannot be removed by scraping. There are several forms such as homogeneous, nonhomogeneous and hairy leukoplakia. A special form is candidal leukoplakia caused by an infection with the fungus Candida albicans. Erythroplakia refers to a red lesion of the oral cavity with extremely high potential for malignant transformation. Oral lichen planus is the name for a chronic mucocutaneous autoimmune disease of the oral mucosa that can be clinically observed in six different forms: papillary, reticular, plaque, atrophic, erosive and bullous. Atrophic and erosive forms have a higher risk of malignant transformation compared to others. Actinic cheilitis is an inflammatory change in the lip area caused by excessive exposure to ultraviolet rays. Diagnosis of premalignant lesions includes detailed anamnesis and clinical examination, oral - laboratory tests, laboratory tests and toluidine test. Properly made diagnoses allow for the right choice of therapy. Treatment includes regular monitoring of lesion progress, non-surgical drug therapy, and surgical removal. The role of dentists is the timely detection and care of lesions and the prevention of possible oral cancer, which significantly changes the quality of life of patients.

• Keywords: neoplazme; oralne; leukoplakija; oralna; Lichen Planus; oralni
• Keywords (english): Mouth Neoplasms; Leukoplakia; Oral; Lichen Planus; Oral
• Language: croatian
• URN:NBN: urn:nbn:hr:127:368936
• Study programme: Title: dental medicine; Study programme type: university; Study level: integrated undergraduate and graduate; Academic / professional title: doktor/doktorica dentalne medicine (doktor/doktorica dentalne medicine)
• Type of resource: Text
• File origin: Born digital
• Access conditions: Open access
• Created on: 2020-11-26 08:40:47