ULOGA ANTIBIOTSKE PROFILAKSE U PREVENCIJI RANOG GUBITKA IMPLANTATA

professional thesis

• Title (english): THE ROLE OF ANTIBIOTIC PROPHYLAXIS IN PREVENTING THE LOSS OF DENTAL IMPLANTS
• Author: Marta Krolo
• Mentor: Tihomir Kuna (mentor)
• Committee member: Mato Sušić (predsjednik povjerenstva)
• Committee member: Tihomir Kuna (član povjerenstva)
• Committee member: Dragana Gabrić (član povjerenstva)
• Committee member: Ana Badovinac (član povjerenstva)
• Granter: University of Zagreb; School of Dental Medicine; (Department of Oral Surgery); Zagreb
• Defense date and country: 2019-03-15, Croatia
• Scientific / art field, discipline and subdiscipline: BIOMEDICINE AND HEALTHCARE; Dental Medicine; Oral Surgery

Abstract

Liječenje gubitka zuba ugradnjom dentalnih implantata danas je postala dominantna stomatološka terapija za mnoge pacijente. Iako su stope uspjeha visoke, 95-97% kod zdravih pacijenata, kod pacijenata koji imaju propisanu terapiju i dalje postoje neuspjesi. Vjeruje se da antibiotska profilaksa prije ugradnje implantata smanjuju stopu neuspjeha. Da bi se dali dokazi koji podupiru pretpostavku da nema statistički značajne razlike između pacijenata koji su profilaktički pili antibiotike prije ugradnje implantata i onih koji nisu, a došlo je do ranog gubitka implantata, elektronsko pretraživanje MEDLINE, PUBMED i Cochrane baze podataka provedeno je do 01.02.2018. godine. Uključene su samo publikacije na engleskom jeziku te randomizirane kontrolne studije, prospektivne i retrospektivne studije na ljudima.Kriterij uključivanja bili su pacijenti kojima je bila indicirana dentalna implantološka terapija. Pacijenti koji su primali neku od sljedećih terapija ili bolovali od navedenih bolesti bilisu isključeni: imunosupresivna terapija, radioterapija u području glave i vrata, nekontroliran dijabetes, trudnoća, antibiotska terapija, rizik od infektivnog endokarditisa, povijest uzimanja bisfosfonata i kemoterapija.Rezultati istraživanja pokazali su različite vrste studija (randomizirana kontrolirana istraživanja, retrospektivne i prospektivne studije). Studije su procijenjene za metodološku kvalitetu analize, ograničenja i potencijalne pristranosti. Analiza je bila kvalitativna zbog varijacija u vrstama studija. U ovomradu nije utvrđena statistički značajna razlika u neuspjehu implantata kod pacijenata koji su primali antibiotsku profilaksu u usporedbi s onima koji nisu. Dobro provedena klinička randomizirana istraživanja potrebna su za ispitivanje učinka antibiotske profilakse u implantologiji. Kako su ispitivane studije bile toliko različite u njihovom dizajnu i rezultatima, nije bilo moguće izvesti meta-analizu. Sve su studije procijenjene pojedinačno i kvalitativno.

Abstract (english)

Dental implants are becoming increasingly prevalent among patients in restoring missing teeth. Although success rates are high at 95-97% in healthy patients, implantologists continue to experience some failure in patients undergoing prescribed treatment. Prophylactic antibiotics are believed to decrease the failure rate if given prior to inserting implants. To provide evidence in support of the hypothesis that there are no significant differences in early implant failure rates if prophylactic antibiotics are (not) given, an electronic search of MEDLINE, PUBMED and the Cochrane data bases was carried out for the period prior to 1 February 2018. Only publications in English were included. Only randomised control trials, prospective cohort studies and retrospective studies on humans were selected. The inclusion criteria included patients who needed dental implant therapy. The exclusion criteria included all patients undergoingcertain treatments such as immunosupresive therapy, chemotherapy, poorly controlled diabetes, pregnancy, antibiotic therapy, those at risk of infective endocarditis, or having a history of bisphosphonates or underoing radiotherapy to the head and neck region. The search results identified various types of studies (randomizied controlled trials, retrospective, and prospective studies). Studies were assessed for methodological quality of the analysis, limitations and potential bias. The analysis was qualitative due to variations in the types of studies. This review found no difference in implant failure between individuals who received implant therapy while taking prophylactic antibiotics compared to patients who received implant therapy while not undergoing prophylactic implant therapy. A well conducted clinical randomised study is necessary to test the effect of prophylactic antibiotics in implant therapy. Gvien that the studies examined were so varied in their design and outcomes, it was not possible to perform a meta-analysis. All studies have been assessed individually and qualitatively.

• Keywords: dentalna implantologija; rani gubitak implantata; antibiotska profilaksa
• Keywords (english): dental implantology; early dental implant failure; prophylactic antibiotics
• Language: croatian
• URN:NBN: urn:nbn:hr:127:957589
• Study programme: Title: dental medicine; Study programme type: university; Study level: postgraduate specialist; Academic / professional title: sveučilišni/a magistar/magistra dentalne medicine (sveučilišni/a magistar/magistra dentalne medicine)
• Type of resource: Text
• File origin: Born digital
• Access conditions: Open access
• Created on: 2019-10-03 10:47:43