Emdogain u parodontnoj kirurgiji

master's thesis

• Title (english): Emdogain in periodontal surgery
• Author: Damir Čes
• Mentor: Andrej Aurer (mentor)
• Committee member: Andrej Aurer (predsjednik povjerenstva)
• Committee member: Ivan Puhar (član povjerenstva)
• Committee member: Tihomir Kuna (član povjerenstva)
• Granter: University of Zagreb; School of Dental Medicine; (Department of Periodontology); Zagreb
• Defense date and country: 2017-07-13, Croatia
• Scientific / art field, discipline and subdiscipline: BIOMEDICINE AND HEALTHCARE; Dental Medicine; Periodontology

Abstract

Parodontitis je jedna od najraširenijih upalnih bolesti koja uništava parodont zuba. Cilj parodontne kirurške terapije je zaustavljanje daljnjeg napredovanja bolesti i regeneracija potpornog tkiva. Upotreba proteina matriksa cakline je postigla zadovoljavajuće rezultate u regenerativnoj parodontnog kirurgiji. Oni djeluju na način da tijekom cijeljenja potiču stvaranje cementa s umetnutim kolagenim vlaknima imitirajući uvjete koji su se odvijali tijekom razvoja zuba.
Djelatne komponente koje imaju regenerativno sposobnost su amelogenini i neamelogenini prisutni u smjesi proteina caklinskog matriksa. Emdogain® je komercijalno dostupan proizvod koji sadrži derivate matriksa cakline svinjskih zametaka, a prisutan je na tržištu preko 20 godina.
Primjena Emdogaina® predstavlja siguran postupak koji rezultira regeneracijom tkiva. Dokazano je da, samostalno primijenjen, ima jednako djelotvoran učinak kao i GTR metoda, dok kombiniranom terapijom EMD-a i GTR-a nije uočena značajnija prednost. Kombinirana primjena s faktorima rasta, alotransplantatima, ksenotransplantatima i aloplastičnim materijalima ima prednost nad samostalnom primjenom EMD-a. Cilj svake kombinirane terapije je povećati kliničku predvidivost i poboljšati ishod regenerativne kirurgije.

Abstract (english)

Periodontitis is one of the most common inflammatory diseases that destroys periodontal structure of the tooth. The objectives of the periodontal surgical therapy are prevention of further disease progression, and regeneration of the supportive tissue. The use of enamel matrix proteins has achieved satisfactory results in regenerative periodontal surgery. During healing, such proteins stimulate the formation of cement with inserted collagen fibres by imitating the conditions that occurred during the development of teeth. Active components that have regenerative capability are amelogenins and neamelogens present in a mixture of enamel matrix protein. Emdogain® is a commercially available product containing porcine germinal matrix derivatives and has been present on the market for over 20 years. Use of Emdogain® is a safe procedure that results in regeneration of the tissue. It has been proved that, if administered alone, it produces the same effect as the GTR method, whereas no significant advantage has been observed in combined EMD and GTR therapy. Using EMD in combination with growth factors, allografts, xenografts and alloplastic material is preferred over using EMD only. The objective of each combination therapy is to increase clinical predictability and improve the outcome of regenerative surgery.

• Keywords: parodontitis; proteini matriksa cakline; Emdogain®
• Keywords (english): periodontitis; enamel matrix proteins; Emdogain®
• Language: croatian
• URN:NBN: urn:nbn:hr:127:071065
• Study programme: Title: dental medicine; Study programme type: university; Study level: integrated undergraduate and graduate; Academic / professional title: doktor/doktorica dentalne medicine (doktor/doktorica dentalne medicine)
• Type of resource: Text
• File origin: Born digital
• Access conditions: Open access
• Created on: 2018-11-20 10:21:21