Rana dijagnostika karcinoma pločastih stanica usne šupljine

master's thesis

• Title (english): Early diagnosis of oral squamous cell carcinoma
• Author: Sara Đureković
• Mentor: Danica Vidović Juras (mentor)
• Granter: University of Zagreb; School of Dental Medicine; Zagreb
• Defense date and country: 2024-09-25, Croatia
• Scientific / art field, discipline and subdiscipline: BIOMEDICINE AND HEALTHCARE; Dental Medicine

Abstract

Karcinom pločastih stanica usne šupljine je zloćudni tumor u regiji glave i vrata koji se može dijagnosticirati u najranijoj fazi, ali se u većini slučajeva dijagnosticira prekasno pa je praćen visokim morbiditetom i mortalitetom. Stomatolozi su u poziciji prepoznati oralne potencijalno zloćudne poremećaje kao i rani oralni karcinom. Za rano prepoznavanje važna je edukacija pacijenata i zdravstvenih djelatnika o ranim znakovima i simptomima zloćudne preobrazbe u usnoj šupljini. Stomatolozi trebaju poznavati trenutačno dostupne metode za ranu dijagnostiku karcinoma, tj. klinički pregled i biopsiju oralnih tkiva kao zlatni standard u dijagnostici, ali i dostupne pomoćne dijagnostičke metode, na bazi fluorescencije tkiva i vitalnih bojila. Ove metode nisu idealne pa se posljednjih godina razvija više novih metoda, manje invazivnih. Neke od tih metoda su analiza uzoraka ekfolijativne citologije i tekuće biopsije, slikovne metode temeljene na vizualizaciji strukture epitela uz pomoć ultrazvučnih signala ili refrakcije svjetlosti i nanočesticama ojačane konvencionalne spektroskopske metode. Iako obećavajuće, nove tehnike nisu još uvijek na stupnju razvoja kako bi se opravdala njihova komercijalna dostupnost i zahtijevaju dodatna istraživanja i edukaciju stručnjaka.

Abstract (english)

Oral cavity squamous cell carcinoma is a malignant tumor located in the head and neck region. Although an early diagnosis is possible, in most cases it is made too late, resulting in high morbidity and mortality rates. Dental practitioners have an opportunity to detect potentially malignant oral disorders and early stages of oral carcinoma. Education of patients and healthcare professionals about the early signs and symptoms of malignant transformations in the oral cavity is crucial for early detection. Dental practitioners should be familiar with currently available methods for early diagnosis of carcinoma, clinical examination and oral tissue biopsy as the diagnostic gold standard, as well as with auxiliary diagnostic techniques based on tissue fluorescence and vital stains. Since these techniques are not perfect, newer, less invasive methods have emerged in recent years. Some of these methods include analysis of exfoliative cytology samples and liquid biopsy, imaging techniques based on visualization of epithelial structure using ultrasound signals or light refraction, and nanoparticle-enhanced conventional spectroscopy methods. Although promising, these new techniques have not yet been sufficiently developed to justify commercial availability and will require additional research and expert training.

• Keywords: karcinom pločastih stanica; oralne novotvorine; rano dijagnosticiranje karcinoma
• Keywords (english): Squamous Cell Carcinoma; Mouth Neoplasms; Early Detection of Cancer
• Language: croatian
• URN:NBN: urn:nbn:hr:127:785249
• Study programme: Title: Dental medicine; Study programme type: university; Study level: integrated undergraduate and graduate; Academic / professional title: doktor/doktorica dentalne medicine (doktor/doktorica dentalne medicine)
• Type of resource: Text
• File origin: Born digital
• Access conditions: Open access
• Created on: 2024-09-24 19:29:08