Cerebrocaskularna bolest kao uzrok pseudobulbarne pareze

master's thesis

• Title (english): Cerebrovascular disease as a cause of pseudobulbar paresis
• Author: Nives Burek
• Mentor: Vida Demarin (mentor)
• Granter: University of Zagreb; School of Dental Medicine; Zagreb
• Defense date and country: 2006, Croatia
• Scientific / art field, discipline and subdiscipline: BIOMEDICINE AND HEALTHCARE; Dental Medicine

Abstract

Glavni patologijski uzrok uključen u okluzivnu ekstrakranijalnu cerebrovaskularnu bolest je ateroskleroza, koja približno tvori 90% svih slučajeva. Aterogenetski rizični faktori su: hiperkolesterolemija, hipertenzija, imunokompleks, virusne infekcije i pušenje.
Masne lezije okružene tankom kapsulom imaju tendenciju pucanja uslijed utjecaja krvne struje i vibracije tokom turbulencije.
Takve forme mogu poslužiti kao objašnjenje patogenetskog mehanizma bolesti. Moždani udar je jedan od najvažnijih problema u današnjoj neurologiji, a multipli lakunarni infrakti koji nastaju kao posljedica moždane mikroangiopatije, a zahvaćaju kortikospinalni i kortikolubularni put, najčešći su uzrok pseudobulbarne pareze. Novije neinvazivne dijagnostike tih aterosklerotičnih promjena su nezamjenjive u klasifikaciji, prevenciji, prognozi i praćenju cerebrovaskularnih bolesti. Ekstrakranijsko Duplex Doppler razmatranje i Color Doppler Flow Imaging omogućuju direktan pogled u morfologiju krvne struje, eventualno prisustvo plaka, strukturu, veličinu i površinu, a Transcranial Doppler (TCD) predstavlja probitak u neurološkoj neinvazivnoj dijagnostici. Obzirom da bolesnici s kliničkom slikom pseudobulbarne pareze često imaju potrebe za stomatološkim zahvatima, a imaju poteškoća s otvaranjem usta i teže su pokretni neophodno je važno da stomatolog zna prepoznati probleme i suočiti se s njima.

Abstract (english)

The main pathologic entity involved in the occlusive extracranial cerebrovascular disease is atherosclerosis, which accounts for approximately 90 percent of all cases. Atherogenetic risk factors are the following: hypercholesterolemia, hypertension,
immunocomplex, viral infection, and tobacco smoke. The lipid lesions surrounded by a thin capsule tend to rupture easily under the influence of blood flow forces and vibration due to turbulence. Such forms may serve as an explanation for the embolic pathogenetic mechanism of the disease. Brain stroke is one of the major problems in today’s neurology and multiple lacunar strokes developing as a result of microangiopathy, spreading to the corticospinal and corticobulbar tract, are the most common causes of pseudobulbar paresis. Early noninvasive diagnostics of these atherosclerotic changes is indispensable in classification, prevention, prognosis and monitoring of cerebrovascular diseases. Extracranial Duplex Doppler evaluation and Color Doppler Flow Imaging provide direct insight into blood vessel morphology, possible presence of plaques, their composition, size and surface. Relatively recently introduced Transcranial Doppler (TCD) evaluation was a real breakthrough in neurological noninvasive diagnostics. Since patients with the clinical picture of pseudobulbar paresis often need stomatological intervention and have difficulty opening the mouth and walking, it is very important for the stomatologist to be able to recognize these problems and deal with them.

• Keywords: cerebrovaskularni poremećaji; pseudobulbarna paraliza
• Keywords (english): Cerebrovascular Disorders; Pseudobulbar Palsy
• Language: croatian
• URN:NBN: urn:nbn:hr:127:104717
• Study programme: Title: Integrated undergraduate and graduate university study of Dental Medicine; Study programme type: university; Study level: integrated undergraduate and graduate; Academic / professional title: doktor dentalne medicine (doktor dentalne medicine)
• Type of resource: Text
• File origin: Born digital
• Access conditions: Closed access
• Created on: 2024-08-29 09:20:51