Eksperimentalni i komercijalni kompozitni materijali s remineralizacijskim učinkom

master's thesis

• Title (english): Experimental and commercial composite materials with remineralizing effect
• Author: Ksenija Dukarić
• Mentor: Matej Par (mentor)
• Granter: University of Zagreb; School of Dental Medicine; (Department of Endodontics and Restorative Dentistry); Zagreb
• Defense date and country: 2024-07-01, Croatia
• Scientific / art field, discipline and subdiscipline: BIOMEDICINE AND HEALTHCARE; Dental Medicine; Endodonics and Restorative Dentistry

Abstract

Kompozitni materijali s remineralizacijskim učinkom sve su više zastupljeni u znanstvenim istraživanjima, a postupno ulaze i u kliničku praksu s ciljem smanjenja pojave sekundarnog karijesa kao najvažnijeg čimbenika neuspjeha kompozitnih restauracija zbog polimerizacijskog skupljanja i posljedičnog nastanka marginalne pukotine. Takvi materijali sadrže aktivna punila koja potiču
remineralizaciju tvrdih zubnih tkiva postupnim otpuštanjem kalcijevih, fosfatnih, fluoridnih i ostalih iona. Uz remineralizaciju do koje dolazi ugradnjom iona u kristalnu rešetku hidroksiapatita tvrdih zubnih tkiva, moguća je i precipitacija kalcijevih fosfata na površini materijala. Jedno od poznatijih punila kompozitnih materijala koje može služiti kao izvor remineralizirajućih iona je
bioaktivno staklo čija se struktura može prilagođavati ovisno o namjeni, stoga je ono danas zastupljeno kao punilo u eksperimentalnim, ali i u nekim komercijalnim kompozitnim materijalima. Pod pojmom „bioaktivnost“ kod bioaktivnog stakla podrazumijeva se otpuštanje remineralizirajućih iona u vodenom mediju i taloženje hidroksiapatita na površini čime se teoretski
može zabrtviti marginalna pukotina. Dodatni učinci bioaktivnog stakla su alkalizacija okolnog vodenog medija i antibakterijski učinak. Najpoznatiji komercijalni kompozitni materijal s remineralizacijskim učinkom je Cention koji zbog zadovoljavajuće estetike i mehaničkih svojstava,mogućnosti postavljanja u jednom debelom sloju, remineralizirajućeg djelovanja i financijske prihvatljivosti predstavlja potencijalnu alternativu konvencionalnim kompozitnim materijalima. Također, dostupni komercijalni kompozitni materijali s remineralizacijskim učinkom su Activa Bioactive, Activa Presto i Surefil One. Nedostatak komercijalnih materijala s remineralizacijskim učinkom jest prebrzi dolazak na tržište i nedovoljno provedenih kliničkih istraživanja kojima bi se pokazao stvarni remineralizacijski učinak na tvrda zubna tkiva.

Abstract (english)

Remineralizing composite materials are increasingly represented in scientific studies and are gradually finding their way into clinical practice in order to reduce the occurrence of secondary caries as the most important factor in the failure of composite restorations due to polymerization shrinkage and the resulting formation of marginal gaps. These materials contain active fillers that stimulate remineralization of the tooth structure through the gradual release of calcium, phosphate,
fluoride and other ions. In addition to remineralization, which occurs through the incorporation of ions into the crystal lattice of the hydroxyapatite of the hard dental tissues, the precipitation of calcium phosphates on the surface of the material is also possible. One of the better-known fillers in composite materials that can serve as a source of remineralizing ions is bioactive glass, the structure of which can be adapted depending on the intended use, which is why it is now included as a filler in experimental, but also in some commercial composite materials. The term "bioactivity" in bioactive glass is used to indicate the release of remineralizing ions in the aqueous medium and the deposition of hydroxyapatite on the surface, which can theoretically seal the marginal gap. Additional effects of bioactive glass include the alkalization of the surrounding aqueous medium and the antibacterial effect. The best-known commercial composite material with a remineralizing effect is Cention, which is a potential alternative to conventional composite materials due to its satisfactory esthetics and mechanical properties, the possibility of applying a thick layer, its remineralizing effect and its financial acceptability, represents a potential alternative to conventional composite materials. Other commercially available remineralizing composite materials include Activa Bioactive, Activa Presto and Surefil One. A major shortcoming of commercial remineralizing materials is their rapid introduction to the dental market, while there is insufficient clinical evidence of their actual remineralizing effect on dental hard tissue.

• Keywords: restorativna stomatologija; kompozitne smole; remineralizacija zuba; sekundarni karijes; bioaktivno staklo; eksperimentalni kompozitni materijali; komercijalni kompozitni materijali
• Keywords (english): Operative Dentistry; Composite Resins; Tooth Remineralization; Secondary Caries; Bioactive Glass; Experimental Composite Materials; Commercial Composite Materials
• Language: croatian
• URN:NBN: urn:nbn:hr:127:682179
• Study programme: Title: Integrated undergraduate and graduate university study of Dental Medicine; Study programme type: university; Study level: integrated undergraduate and graduate; Academic / professional title: doktor dentalne medicine (doktor dentalne medicine)
• Type of resource: Text
• File origin: Born digital
• Access conditions: Open access
• Created on: 2024-06-27 06:56:30