Periochip® i njegova primjena u terapiji parodontnih bolesti

master's thesis

• Author: Domagoj Prebeg
• Mentor: Andrej Aurer (mentor)
• Granter: University of Zagreb; School of Dental Medicine; Zagreb
• Defense date and country: 2004, Croatia
• Scientific / art field, discipline and subdiscipline: BIOMEDICINE AND HEALTHCARE; Dental Medicine; Periodontology

Abstract

Parodontna bolest je kronična upalna destruktivna bolest koja zahvaća potporni aparat zuba. Najučestaliji oblik parodontne bolesti je kronični parodontitis. Glavni simptomi su gubitak pričvrstka (CAL) i stvaranje džepa. Parodontitis je uzrokovan bakterijama i njihovim produktima koje nalazimo u džepu i na površini korijena. One uzrokuju obrambenu reakciju domaćina zbog koje dolazi do promjena u parodontu, što neizbježno dovodi do oštećenja tkiva i razvoja bolesti koja se ne može zaustaviti bez parodontološke terapije. Scaling i root planing (SRP) je inicijalni oblik terapije parodontitisa koji uklanja tvrde i meke zubne naslage iz džepa i s površine korijena. SRP uklanja veliku većinu patogenih bakterija iz aktivnog džepa ali je često neučinkovit kod dubokih džepova. Stoga je u tih pacijenata indicirana dodatna antimikrobna terapija PerioChipom. Primjena PerioChipa nakon provedenog scalinga i root planinga (SRP), oslobađa klorheksidin u parodontni džep u dostatnoj koncentraciji u tijekom sedam do deset dana, eliminira patogene bakterije džepa u tom razdoblju i disocira se nakon 7-10 dana enzimskom razgradnjom. On reducira količinu patogenih bakterija džepa i do 3 mjeseca, pa je stoga siguran i učinkovit kod liječenja kroničnog parodontitisa. U usporedbi sa samostalnom primjenom SRP-a značajno smanjuje dubinu džepa, reducira krvarenje pri sondiranju (BOP) i smanjuje gubitak pričvrstka (CAL) u
periodu od 6 mjeseci i duže kod džepova dubljih od 7 mm. PerioChip reducira gingivnu upalu, ne boji zube i uzrokuje minimalne ili nikakve popratne pojave.

Abstract (english)

Periodontitis is a destructive, chronic inflammatory process effecting the periodontal attachement apparatus. The most common form of periodontitis is chronic peridontitis. The primary symptoms of periodontitis are attachment loss (CAL) and pocket formation. Periodontitis is a result of bacteria and their products that reside on the root and in the pocket and influence the periodontal pocket environment by eliciting the host defense reaction. Periodontitis, inevitably, results in
tissue damage. Spontaneous untreated healing rarely occures. Scaling and root planing (SRP) is the most common intervention to remove plaque and calculus, which are extensively contaminated with microorganisms and their toxins. SRP eliminates most of the pathogenic bacteria present in inflamed pocket but is often ineffective in deep pockets. Thus, the adjunctive use of antibacterial agents (PerioChip) with SRP enhances the results of treatment. PerioChip following SRP, releases chlorhexidine in periodontal pockets at effective levels over seven to ten days, eliminates pathogenic bacteria in that period of time, and disintegrates within 7-10 days due to enzymatic degradation. It also reduces amount of pathogenic bacteria in the pocket for up to 3 months. PerioChip is a safe and effective local adjunctive treatment for chronic adult periodontitis. It provides a significant reduction of periodontal probing pocket depth compared to scaling and root planing alone, reduces bleeding on probing (BOP), improves significantly (at 6 months or or longer) the probing attachment level compared to scaling and root planing alone for pockets deeper than 7 mm. It also reduces gingival inflammation, and does not stain the teeth and causes minimal or no adverse effects.

• Keywords: parodontne bolesti; kiretaža
• Keywords (english): Periodontal Diseases; Dental Scaling
• Language: croatian
• URN:NBN: urn:nbn:hr:127:026308
• Study programme: Title: dental medicine; Study programme type: university; Study level: integrated undergraduate and graduate; Academic / professional title: doktor/doktorica dentalne medicine (doktor/doktorica dentalne medicine)
• Type of resource: Text
• File origin: Born digital
• Access conditions: Closed access
• Created on: 2024-06-03 10:38:35