Oralne reakcije na lijekove

master's thesis

• Author: Ana Kukučka
• Mentor: Vanja Vučićević-Boras (mentor)
• Committee member: Vanja Vučićević-Boras (predsjednik povjerenstva)
• Committee member: Vlaho Brailo (član povjerenstva)
• Committee member: Dragana Gabrić (član povjerenstva)
• Granter: University of Zagreb; School of Dental Medicine; (Department of Oral Medicine); Zagreb
• Defense date and country: 2016-07-14, Croatia
• Scientific / art field, discipline and subdiscipline: BIOMEDICINE AND HEALTHCARE; Dental Medicine; Oral Medicine

Abstract

Svaki lijek, osim poţeljnog učinka, ima i negativne. Nuspojave na lijek se
mogu pojaviti i kada je lijek korišten u standardnim dozama i oblicima primjene.
Reakcija na lijek se moţe dogoditi odmah nakon primjene lijeka ili nakon nekoliko
godina korištenja. Nuspojave na lijekove se mogu manifestirati na različitim
dijelovima tijela i organima. U usnoj šupljini moţe biti pogoĎen svaki dio sluznice,
bilo da su lijekovi korišteni sistemski ili lokalno. Oralne reakcije na lijekove
karakterizira raznovrsnost kliničkih lezija i simptoma, te ih je stoga teško prepoznati.
Nuspojave sistemskih lijekova su brojne, ali najčešće su kserostomija, promjene
okusa, simptomi ''gorućih'' usta, oralne ulceracije, multiformni eritem, hiperplazija
gingive, lihenoidna reakcija, pemfigus, angioedem, fiksna erupcija, kontaktna
alergija. Stomatolog treba dobro poznavati farmakološko djelovanje, terapijsku
primjenu nuspojave svakog lijeka, kao i terapiju eventualnih nepoţeljnih reakcija.
Liječenje nuspojava se temelji na uklanjanju lijeka koji je doveo do reakcije i na
terapiji oralnih promjena, najčešće primjenom lokalnih ili sistemskih kortikosteroida.

Abstract (english)

Every drug, apart from the desired effect might have an unwanted side-effect.
Side effects of the drugs may occur if the drug is used in standard doses and forms of
application. Drug reactions can occur immediately after the administration of the
drug or after a few years of use. Adverse reactions to drugs can manifest in different
parts of the body. In the oral cavity, every part of the oral mucosa can be affected
which may be a result of medications taken either locally or systemically. Oral drug
reactions are characterized by a variety of clinical symptoms and lesions and
therefore are not easy to recognize. Adverse effects of systemic medications might be
numerous, but frequently noted are xerostomia, taste disturbances, burning mouth
symptoms, oral ulcerations, erythema multiforme, gingival hyperplasia, lichenoid
reaction, pemphigus, fixed drug eruption, angioedema, contact allergy. Dentists must
be aware of pharmacologic actions, therapeutic use and adverse effects of each drug,
knowing how to control the consequences of drug therapy. Therapy is based on the
immediate exclusion of the offended drug and treatment of oral lesions, most
commonly by use of local or systemic corticosteroids.

• Keywords: oralne manifestacije; klinička farmakologija
• Keywords (english): oral manifestations; pharmacology; clinical
• Language: croatian
• URN:NBN: urn:nbn:hr:127:519974
• Study programme: Title: dental medicine; Study programme type: university; Study level: integrated undergraduate and graduate; Academic / professional title: doktor/doktorica dentalne medicine (doktor/doktorica dentalne medicine)
• Type of resource: Text
• File origin: Born digital
• Access conditions: Open access
• Created on: 2016-11-14 10:07:55