Oralne nuspojave terapije kortikosteroidima

master's thesis

• Title (english): Oral side effects of corticosteroid therapy
• Author: Iva Laginja
• Mentor: Ivana Šutej (mentor)
• Committee member: Ivana Šutej (predsjednik povjerenstva)
• Committee member: Željko Verzak (član povjerenstva)
• Committee member: Kristina Peroš (član povjerenstva)
• Granter: University of Zagreb; School of Dental Medicine; (Chair of Pharmacology); Zagreb
• Defense date and country: 2016-09-06, Croatia
• Scientific / art field, discipline and subdiscipline: BIOMEDICINE AND HEALTHCARE; Dental Medicine

Abstract

Kortikosteriodi su skupina hormona koje luče nadbubrežne žlijezde.
Mineralokortikoide, glukokortikoide i adrenalne androgene hormone izlučuje kora,
dok srž nadbubrežne žlijezde luči adrenalin i noradrenalin. Kortikosteriodni lijekovi
su sintetski ekvivalenti prirodnih kortikosteroida kojima su neke farmakološke
osobine istaknute, a druge potisnute. Danas se najviše koriste zbog svojega
protuupalnog i imunosupresivnog učinka. Ipak, uporaba kortikosteroida u liječenju
danas je ograničena zbog mnogih nuspojava poput neuroloških, gastrointestinalnih,
mišićnih, kardiovaskularnih i dermatoloških smetnji te osteoporoze, adrenalne
supresije, hiperglikemije, dijabetesa i mnogih drugih.
U stomatologiji se kortikosteroidi koriste kako bi ublažili bol i upalu te pri
liječenju nekih oralnih bolesti poput oralnih ulceracija, vezikulobuloznih lezija,
oralnog lichena planusa, preosjetljivosti zubne pulpe, temporomandibularnih
poremećaja, anafilakse ili drugih alergoloških reakcija. Od oralnih nuspojava može
doći do osjeta suhoće usta i promijenjenog okusa, pojave candide albicans, osjeta
suhoće grla, natečenosti usta i dr.

Abstract (english)

Corticosteroids are a group of hormones secreted by adrenal glands.
Mineralcorticoids, glucocorticoids and adrenal androgens are secreted by the cortex
while adrenaline and noradrenaline are secreted by the core of the adrenal gland.
Corticosteroid medications are synthetic equivalents of natural corticosteroids with
some pharmacological features emphasized and others repressed. Nowadays they are
mainly used for their antiinflamatory and immunosuppressive effects. However, the
usage of corticosteroids is limited because of many side effects, such as neurological,
gastrointestinal, muscular, cardiovascular and dermatological disorders, osteoporosis,
adrenal suppression, hyperglycemia, diabetes etc. In stomatology corticosteroids are
used for appeasing pain and inflammation, also in oral diseases treatment, such as
oral ulcerations, vesiculobullous lesions, oral lichen planus, hypersensitivity of
dental pulp, temporomandibular disorders, anaphylaxis or other allergic reactions.
Oral side effects can cause the feeling of dry mouth and altered sense of taste,
appearance of Candida albicans, the feeling of dry throat, swollen lips etc.

• Keywords: hormoni kore nadbubrežne žlijezde; oralne manifestacije
• Keywords (english): adrenal cortex hormones; oral manifestations
• Language: croatian
• URN:NBN: urn:nbn:hr:127:052506
• Study programme: Title: dental medicine; Study programme type: university; Study level: integrated undergraduate and graduate; Academic / professional title: doktor/doktorica dentalne medicine (doktor/doktorica dentalne medicine)
• Type of resource: Text
• File origin: Born digital
• Access conditions: Open access
• Created on: 2016-11-11 12:40:21