Influence of Systemic Diseases on Oral Microbiota

master's thesis

• Title (english): Utjecaj sustavnih bolesti na oralnu microbiotu
• Author: Taja Urbančič-Rak
• Mentor: Ivan Puhar (mentor)
• Granter: University of Zagreb; School of Dental Medicine; Zagreb
• Defense date and country: 2023-07-10, Croatia
• Scientific / art field, discipline and subdiscipline: BIOMEDICINE AND HEALTHCARE; Dental Medicine; Periodontology

Abstract

Oral microbiota harbours a wide array of microorganisms, including bacteria, fungi, archaea, viruses, and protozoa, and plays a crucial role in maintaining oral health. However, systemic diseases can significantly impact the composition and dynamics of the microbial community within the oral cavity, which may lead to oral health complications as well as deterioration of the systemic diseases themselves. Available evidence has shown an association between several systemic diseases and oral dysbiosis. These conditions include hormone-related diseases, autoimmune diseases, hyposialia, liver diseases, neoplasms, and associated therapy. Understanding the impact of systemic diseases on the oral microbiota is vital for developing effective strategies to manage oral health in individuals with these conditions. Targeted interventions aimed at restoring microbial balance, along with appropriate oral hygiene practices and regular dental care, can help mitigate the negative impact of systemic diseases on oral health.

Abstract (croatian)

Mikrobiom usne šupljine sadrži različite mikroorganizme, uključujući bakterije, gljivice, arheje, viruse i protozoe te igra ključnu ulogu u održavanju oralnog zdravlja. Međutim, sistemske bolesti mogu značajno utjecati na sastav i dinamiku mikrobne zajednice unutar usne šupljine, što može dovesti do komplikacija oralnog zdravlja, kao i pogoršanja samih sistemskih bolesti. Trenutačno dostupni dokazi pokazuju povezanost između nekoliko sistemskih bolesti i oralne disbioze. Ta stanja uključuju bolesti vezane uz hormone, autoimune bolesti, hiposijaliju, bolesti jetre i neoplazme s pripadajućom terapijom. Razumijevanje utjecaja sistemskih bolesti na oralnu mikrobiotu ključno je za razvoj učinkovitih strategija za upravljanje oralnim zdravljem kod pojedinaca s ovim stanjima. Ciljane intervencije usmjerene na ponovno uspostavljanje mikrobne ravnoteže, uz odgovarajuću praksu oralne higijene i redovitu stomatološku njegu, mogu pomoći u ublažavanju negativnih posljedica sistemskih bolesti na oralno zdravlje.

• Keywords: oral microbiota; oral dysbiosis; systemic diseases; oral hygiene; oral health
• Keywords (croatian): oralna mikrobiota; oralna disbioza; sistemske bolesti; oralna higijena; oralno zdravlje
• Language: english
• URN:NBN: urn:nbn:hr:127:272657
• Study programme: Title: Integrated undergraduate and graduate university study of Dental Medicine; Study programme type: university; Study level: integrated undergraduate and graduate; Academic / professional title: doktor/doktorica dentalne medicine (doktor/doktorica dentalne medicine)
• Type of resource: Text
• File origin: Born digital
• Access conditions: Open access
• Created on: 2023-07-04 09:57:03