Treatment of Intrabony Defects with a Combination of Hyaluronic Acid and Deproteinized Porcine Bone Mineral

Scientific paper - Original scientific paper

• Author: Darko Božić
• Author: Ivan Ćatović
• Author: Ana Badovinac
• Author: Larisa Musić
• Author: Matej Par
• Author: Anton Sculean
• Author's institution: University of Zagreb; School of Dental Medicine; (Department of Endodontics and Restorative Dentistry)
• Author's institution: University of Zagreb; School of Dental Medicine; (Department of Periodontology)
• Scientific / art field, discipline and subdiscipline: BIOMEDICINE AND HEALTHCARE; Dental Medicine

Abstract (english)

Background: this study evaluates the clinical outcomes of a novel approach in treating deep intrabony defects utilizing papilla preservation techniques with a combination of hyaluronic acid (HA) and deproteinized porcine bone mineral. Methods: 23 patients with 27 intrabony defects were treated with a combination of HA and deproteinized porcine bone mineral. Clinical attachment level (CAL), pocket probing depth (PPD), gingival recession (REC) were recorded at baseline and 6 months after the surgery. Results: At 6 months, there was a significant CAL gain of 3.65 ± 1.67 mm (p < 0.001) with a PPD reduction of 4.54 ± 1.65 mm (p < 0.001), which was associated with an increase in gingival recession (0.89 ± 0.59 mm, p < 0.001). The percentage of pocket resolution based on a PPD ≤4 mm was 92.6% and the failure rate based on a PPD of 5 mm was 7.4%. Conclusions: the present findings indicate that applying a combined HA and xenograft approach in deep intrabony defects provides clinically relevant CAL gains and PPD reductions compared to baseline values and is a valid new approach in treating intrabony defects.

• Keywords (english): hyaluronic acid; periodontal regeneration; intrabony defects; microsurgery; periodontitis; surgical flaps
• Language: english
• Publication type: Scientific paper - Original scientific paper
• Publication status: Published
• Peer review: Peer review - international
• Publication version: Published version
• Journal title: Materials
• Numbering: vol. 14, no. 22, 6795
• e-ISSN: 1996-1944
• DOI: https://doi.org/10.3390/ma14226795
• URN:NBN: urn:nbn:hr:127:844765
• Publication: 2021-11-11
• Document URL: https://www.mdpi.com/1996-1944/14/22/6795
• Type of resource: Text
• Access conditions: Open access
• Created on: 2022-11-04 08:47:22