prikaz prve stranice dokumenta Psychiatric Illness or Immune Dysfunction—Brain Perfusion Imaging Providing the Answer in a Case of Anti-NMDAR Encephalitis
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Scientific paper - Original scientific paper
Psychiatric Illness or Immune Dysfunction—Brain Perfusion Imaging Providing the Answer in a Case of Anti-NMDAR Encephalitis
Diagnostics, 12 (2022), 10; 2377. https://doi.org/10.3390/diagnostics12102377
Šiško Markoš, Ines; Blažeković, Ivan; Peitl, Vjekoslav; Jukić, Tomislav; Supanc, Višnja; Karlović, Dalibor; Fröbe, Ana

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Šiško Markoš, I., Blažeković, I., Peitl, V., Jukić, T., Supanc, V., Karlović, D. & Fröbe, A. (2022). Psychiatric Illness or Immune Dysfunction—Brain Perfusion Imaging Providing the Answer in a Case of Anti-NMDAR Encephalitis. Diagnostics, 12. (10). doi: 10.3390/diagnostics12102377

Šiško Markoš, Ines, et al. "Psychiatric Illness or Immune Dysfunction—Brain Perfusion Imaging Providing the Answer in a Case of Anti-NMDAR Encephalitis." Diagnostics, vol. 12, no. 10, 2022. https://doi.org/10.3390/diagnostics12102377

Šiško Markoš, Ines, Ivan Blažeković, Vjekoslav Peitl, Tomislav Jukić, Višnja Supanc, Dalibor Karlović and Ana Fröbe. "Psychiatric Illness or Immune Dysfunction—Brain Perfusion Imaging Providing the Answer in a Case of Anti-NMDAR Encephalitis." Diagnostics 12, no. 10 (2022). https://doi.org/10.3390/diagnostics12102377

Šiško Markoš, I., et al. (2022) 'Psychiatric Illness or Immune Dysfunction—Brain Perfusion Imaging Providing the Answer in a Case of Anti-NMDAR Encephalitis', Diagnostics, 12(10). doi: 10.3390/diagnostics12102377

Šiško Markoš I, Blažeković I, Peitl V, Jukić T, Supanc V, Karlović D, and sur.. Psychiatric Illness or Immune Dysfunction—Brain Perfusion Imaging Providing the Answer in a Case of Anti-NMDAR Encephalitis. Diagnostics [Internet]. 2022 September 30 [cited 2024 April 16];12(10). doi: 10.3390/diagnostics12102377

I. Šiško Markoš, et al., "Psychiatric Illness or Immune Dysfunction—Brain Perfusion Imaging Providing the Answer in a Case of Anti-NMDAR Encephalitis", Diagnostics, vol. 12, no. 10, September 2022. [Online]. Available at: https://urn.nsk.hr/urn:nbn:hr:127:201521. [Accessed: 16 April 2024]

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Metadata
Title (english)Psychiatric Illness or Immune Dysfunction—Brain Perfusion Imaging Providing the Answer in a Case of Anti-NMDAR Encephalitis
AuthorInes Šiško Markoš
AuthorIvan Blažeković
AuthorVjekoslav Peitl
AuthorTomislav Jukić
AuthorVišnja Supanc
AuthorDalibor Karlović
AuthorAna Fröbe
Author's institutionCatholic University of Croatia
Author's institutionUniversity of Zagreb
School of Dental Medicine
Scientific / art field,
discipline and subdiscipline		BIOMEDICINE AND HEALTHCARE
Clinical Medical Sciences
Abstract (english)
Background: We investigated the potential use of SPECT quantification in addition to qualitative brain perfusion analysis for the detection of anti-NMDAR encephalitis. The question is how to normalize brain activity to be able to quantitatively detect perfusion patterns. Usually, brain activity is normalized to a structure considered unaffected by the disease. Methods: Brain [99mTc]-HMPAO SPECT was performed as a method to detect brain perfusion patterns. The patterns of abnormal brain perfusion cannot always be reliably and qualitatively assessed when dealing with rare diseases. Recent advances in SPECT quantification using commercial software have enabled more objective and detailed analysis of brain perfusion. The cerebellum and whole brain were used as the normalization structures and were compared with visual analysis. Results: The quantification analysis performed with whole brain normalization confirmed right parietal lobe hypoperfusion while also detecting statistically significant left-to-right perfusion differences between the temporal lobe and thalamus. Whole brain normalization further described bilateral frontal lobe hyperperfusion, predominantly of the left lobe, and was in accordance with visual analysis. Conclusion: SPECT quantitative brain perfusion analysis, using the whole brain as the normalization structure rather than the cerebellum, in this case, improved confidence in the visual detection of anti-NMDAR encephalitis and provided unexpected solutions to atypical psychiatric dilemmas.
Keywords (english)
Languageenglish
Publication typeScientific paper - Original scientific paper
Publication statusPublished
Peer reviewPeer review - international
Publication versionPublished version
Journal titleDiagnostics
Numberingvol. 12, no. 10, 2377
e-ISSN2075-4418
DOIhttps://doi.org/10.3390/diagnostics12102377
URN:NBNurn:nbn:hr:127:201521
Publication2022-09-30
Document URLhttps://www.mdpi.com/2075-4418/12/10/2377
Type of resourceText
Access conditionsOpen access
Terms of useLicence Attribution 4.0 International (CC BY 4.0) icon
Created on2022-11-02 09:33:42