Oralni mukozitis

master's thesis

• Title (english): Oral mucositis
• Author: Lucija Kostešić
• Mentor: Božana Lončar Brzak (mentor)
• Committee member: Božana Lončar Brzak (predsjednik povjerenstva)
• Committee member: Ana Andabak Rogulj (član povjerenstva)
• Committee member: Ivana Škrinjar (član povjerenstva)
• Granter: University of Zagreb; School of Dental Medicine; (Department of Oral Medicine); Zagreb
• Defense date and country: 2022-07-14, Croatia
• Scientific / art field, discipline and subdiscipline: BIOMEDICINE AND HEALTHCARE; Dental Medicine; Oral Medicine

Abstract

Mukozitis je bolna, ulcerozna upala koja nastaje uslijed citotoksičnog učinka kemoterapije i radioterapije na epitelne stanice sluznice te zahvaća sluznicu gastrointestinalnog sustava, kojem pripada i sluznica usta i ždrijela. Prezentira se najčešće kao eritem, atrofija ili ulceracija sluznice. Pojavljuje se u gotovo svih pacijenata koji primaju terapiju zračenjem u području glave i vrata, u 20 do 40 % pacijenata na kemoterapiji te 60 do 85 % bolesnika koji idu na transplantaciju hematopoetskih matičnih stanica. Mukozitis se razvija nekoliko dana nakon početka terapije, najčešće između prvog i drugog tjedna, prisutan je dok traje terapija te prestaje dva do četiri tjedna nakon završetka terapije. Podatci iz literature pokazuju da je 19 % pacijenata liječenih kemoterapijom i zračenjem u području glave i vrata hospitalizirano uslijed razvoja teškog oblika oralnog mukozitisa. Posljedično, odgađa se antineoplastična terapija dok
ne nastupi poboljšanje stanja, smanjena je kvaliteta života, lošija prognoza osnovne bolesti i rastu troškovi liječenja pacijenta. Ključno je informirati pacijenta o ovoj mogućoj nuspojavi terapije karcinoma i o dostupnim načinima liječenja koji će olakšati simptome i omogućiti neprekinuto provođenje liječenja osnovne bolesti, za optimalan terapijski učinak.

Abstract (english)

Mucositis is a painful, ulcerative inflammation that occurs due to the cytotoxic effect of chemotherapy and radiotherapy on the epithelial cells of the mucosa and affects the mucosa of the gastrointestinal system, which includes the mucous membranes of the mouth and throat. It is most commonly presented as erythema, atrophy, or ulceration of the mucosa. It occurs in almost all patients receiving radiation therapy of the head and neck, in 20-40% of patients on chemotherapy and 60-85% of patients undergoing hematopoietic stem cell transplantation. Mucositis develops a few days after the start of therapy, usually between the first and second week, lasts the entire duration of the therapy and stops two to four weeks after the end of therapy. Data from the literature show that 19% of patients treated with chemotherapy and radiation of the head and neck area were hospitalized due to the development of severe oral mucositis. Consequently, antineoplastic therapy delayed until the condition improves. The quality of life is reduced; poorer prognosis of the underlying disease is given, and the cost of treating the patient increased. It is crucial to inform the patient on this possible side effect of cancer therapy and on the available treatments that will alleviate the symptoms and allow continuous treatment of the underlying disease, for optimal therapeutic effect.

• Keywords: oralni mukozitis; terapija lijekovima; liječenje zračenjem; radioterapija
• Keywords (english): Oral Mucositis; Drug Therapy; Radiotherapy
• Language: croatian
• URN:NBN: urn:nbn:hr:127:447212
• Study programme: Title: dental medicine; Study programme type: university; Study level: integrated undergraduate and graduate; Academic / professional title: doktor/doktorica dentalne medicine (doktor/doktorica dentalne medicine)
• Type of resource: Text
• File origin: Born digital
• Access conditions: Open access
• Created on: 2022-10-19 08:06:50