Matične stanice i njihova primjena u regeneraciji zubnih tkiva

master's thesis

• Title (english): Stem cells and their use in dental tissue regeneration
• Author: Monika Medved
• Mentor: Ivana Savić Pavičin (mentor)
• Committee member: Ivana Savić Pavičin
• Committee member: Nada Galić
• Committee member: Silvana Jukić Krmek
• Granter: University of Zagreb; School of Dental Medicine; (Department of Dental Anthropology); Zagreb
• Defense date and country: 2015-07-16, Croatia
• Scientific / art field, discipline and subdiscipline: BIOMEDICINE AND HEALTHCARE; Dental Medicine; Morphology of the Dental Tissue System

Abstract

Potraga za novim načinima liječenja dovela je do istraživanja matičnih stanica. Postoje dva tipa matičnih stanica: embrionalne matične stanice i odrasle mezenhimalne matične stanice. Embrionalne matične stanice izolirane su iz unutrašnje stanične mase blastociste, dok su odrasle matične stanice pronađene u različitim tkivima kao što je koštana srž, masno tkivo, potkožno tkivo, mišići i periferna krv. Različite metode koriste se za izolaciju stanica. One uključuju izolaciju uz pomoć enzima, magneta, florescencije ili uzgoja stanica.
Matične stanice predmet su istraživanja različitih grana dentalne medicine. Provedena su brojna klinička istraživanja koja pokazuju dobre rezultate primjene matičnih stanica u kirurgiji prilikom korištenja implantata i sinus liftinga, za regeneraciju parodontnog ligamenta, oralne sluznice, a napreduje čak i razvoj funkcionalnog pulpodentinskog kompleksa. Novija istraživanja koriste signalne molekule i posebno dizajnirane nosače kako bi ciljano usmjerili ponašanje matičnih stanica. Njihov razvoj dovest će do novih rješenja mnogih kliničkih problema koja predstavljaju izazov čak i u današnjoj, modernoj dentalnoj medicini.

Abstract (english)

The quest for alternative ways of treatment led to stem cells research. There are two types of stem cells: embryonic stem cells and adult mesenchymal stem cells. Embryonic stem cells constitute cells isolated from the inner cell mass of blastocysts whereas adult stem cells were found in various tissues like bone marrow, adipose tissue, dermis, muscles and peripheral blood. Different methods, which include the use of enzymes, magnets, fluorescence or cell cultivation, are used for stem cell isolation. Stem cells have been researched by many dentistry branches. There are numerous clinical studies that show good results in the application of stem cells in surgery, when using implants and sinus lifting, for the regeneration of the periodontal ligament, the oral mucosa and even the development of a functional pulpo dentinal complex has showed great progress. More recent research has demonstrated the necessity to influence stem cells using signal molecules and specially designed scaffolds. Their development will lead to solving many clinical conditions that even contemporary dentistry finds challenging.

• Keywords: zubne matične stanice
• Keywords (english): dental stem cells
• Language: croatian
• URN:NBN: urn:nbn:hr:127:356605
• Study programme: Title: dental medicine; Study programme type: university; Study level: integrated undergraduate and graduate; Academic / professional title: doktor/doktorica dentalne medicine (doktor/doktorica dentalne medicine)
• Type of resource: Text
• File origin: Born digital
• Access conditions: Open access
• Created on: 2016-04-04 13:19:31